2. Gene
  3. ARL1 - ADP ribosylation factor like GTPase 1 Gene

ARL1 - ADP ribosylation factor like GTPase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARFL1

Gene ID: 400 | Gene type: protein coding

About ARL1

Cytogenetic location: 12q23.2 Genomic coordinates (GRCh38): 12:101,393,116-101,407,820 (from NCBI)

This gene has 11 transcripts (splice variants), 210 orthologues and 30 paralogues. Ubiquitous expression in thyroid (RPKM 47.8), prostate (RPKM 38.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a Phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

ARL1 Products(2)

mRNA Protein Name
NM_001177.6 NP_001168.1 ADP-ribosylation factor-like protein 1 isoform 1
NM_001301068.1 NP_001287997.1 ADP-ribosylation factor-like protein 1 isoform 2

ARL1 Protein Structure

Arf

Arf: ADP-ribosylation factor family (5 - 176)

  • 0
  • 100
  • 181 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor-like protein 1

ADP-ribosylation factor-like 1

Related Diseases

Diseases Alias
Cholera

Vibrio Cholerae Infection

Cholera - Vibrio Cholerae

Cholera Due To Vibrio Cholerae

Vibrio Cholerae

Cholera Syndrome

Asiatic Cholera

Epidemic Cholera
Spondyloepiphyseal Dysplasia Congenita

SEDC

Sed Congenita

Spondyloepiphyseal Dysplasia, Congenital Type

Late Spondyloepiphyseal Dysplasia

Sed, Congenital Type

Congenital Spondyloepiphyseal Dysplasia

Spranger-Wiedemann Disease

Spondyloepiphyseal Dysplasia Congenital Type

Dysplasia, Spondyloepiphyseal, Congenita

Spondyloepiphyseal Dysplasia, Congenita

Spondyloepiphyseal Dysplasia Tarda, X-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00977 ARL1 Human Pre-designed siRNA Set A / Unkown
HY-W012017 2-Hydroxytetradecanoic acid Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARL1 MGD MGI:99436
Canis familiaris ARL1 VGNC VGNC:38104
Rattus norvegicus ARL1 RGD RGD:621326
Macaca mulatta ARL1 VGNC VGNC:70016
Bos taurus ARL1 VGNC VGNC:26135
Felis catus ARL1 VGNC VGNC:68201