ARL1 - ADP ribosylation factor like GTPase 1 Gene

Also Known as ARFL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 400

About ARL1

Cytogenetic location: 12q23.2 Genomic coordinates (GRCh38): 12:101,393,116-101,407,820 (from NCBI)

This gene has 11 transcripts (splice variants), 210 orthologues and 30 paralogues. Ubiquitous expression in thyroid (RPKM 47.8), prostate (RPKM 38.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a Phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

ARL1 Products (2)

mRNA Protein Name
NM_001177.6 NP_001168.1 ADP-ribosylation factor-like protein 1 isoform 1
NM_001301068.1 NP_001287997.1 ADP-ribosylation factor-like protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP binding IDA
IDA: Inferred from direct assay
9624189 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
8798635 GOA
enables enzyme activator activity IDA
IDA: Inferred from direct assay
9624189 GOA
enables phospholipase D activator activity IDA
IDA: Inferred from direct assay
9624189 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22981988 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
14580338 GOA
Biological Process GO Annotation Evidence References Source
involved in protein localization to Golgi apparatus IMP
IMP: Inferred from mutant phenotype
19224922 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: Inferred from mutant phenotype
19224922 GOA
involved in toxin metabolic process IDA
IDA: Inferred from direct assay
9624189 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
19224922 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
17488291 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL1 Protein Structure

Arf

Arf: ADP-ribosylation factor family (5 - 176)

  • 0
  • 100
  • 181 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor-like protein 1

  • ADP-ribosylation factor-like 1

Related Diseases

Diseases Alias
Cholera

  • Vibrio Cholerae Infection

  • Cholera - Vibrio Cholerae

  • Cholera Due To Vibrio Cholerae

  • Vibrio Cholerae

  • Cholera Syndrome

  • Asiatic Cholera

  • Epidemic Cholera
Spondyloepiphyseal Dysplasia Congenita

  • SEDC

  • Sed Congenita

  • Spondyloepiphyseal Dysplasia, Congenital Type

  • Late Spondyloepiphyseal Dysplasia

  • Sed, Congenital Type

  • Congenital Spondyloepiphyseal Dysplasia

  • Spranger-Wiedemann Disease

  • Spondyloepiphyseal Dysplasia Congenital Type

  • Dysplasia, Spondyloepiphyseal, Congenita

  • Spondyloepiphyseal Dysplasia, Congenita

  • Spondyloepiphyseal Dysplasia Tarda, X-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W012017 2-Hydroxytetradecanoic acid Inhibitor 99.91% Unkown
HY-RS00533 AKR1B10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00977 ARL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARL1 MGD MGI:99436
Canis familiaris ARL1 VGNC VGNC:38104
Rattus norvegicus ARL1 RGD RGD:621326
Macaca mulatta ARL1 VGNC VGNC:70016
Bos taurus ARL1 VGNC VGNC:26135
Felis catus ARL1 VGNC VGNC:68201
Others ARL1 NCBI