LY6H - lymphocyte antigen 6 family member H Gene

Also Known as NMLY6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4062

About LY6H

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,157,916-143,160,654 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 86 orthologues and 1 paralogue. Biased expression in brain (RPKM 15.6), stomach (RPKM 1.2) and 1 other tissue.

Summary

Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

LY6H Products (3)

mRNA Protein Name
NM_001130478.2 NP_001123950.1 lymphocyte antigen 6H isoform b precursor
NM_001135655.2 NP_001129127.1 lymphocyte antigen 6H isoform b precursor
NM_002347.5 NP_002338.3 lymphocyte antigen 6H isoform a precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LY6H Protein Structure

UPAR_LY6

UPAR_LY6: u-PAR/Ly-6 domain (28 - 111)

  • 0
  • 100
  • 140 a.a.
Protein Preferred Names Protein Names

lymphocyte antigen 6H

  • ly-6H

LY6H Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LY6H O94772 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
LY6H O94772 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LY6H Proteins

Cat. No. Product Name Accession Purity
HY-P70217 Lymphocyte antigen 6H/LY6H Protein, Human (HEK293, His) O94772 (L26-G115) ≥ 95%, as determined by reducing SDS-PAGE.

LY6H Antibodies

Cat. No. Product Name Application Reactivity
HY-P810212 Ly-6H Antibody (YA9556) WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA human

Related Diseases

Diseases Alias
Variola Minor

  • Alastrim

  • Cottonpox

  • Milkpox

  • Whitepox
Vertebral Artery Occlusion

  • Occlusion And Stenosis Of Vertebral Artery
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07901 LY6H Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21369 Ly6h Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27888 Ly6h Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LY6H VGNC VGNC:74462
Mus musculus LY6H MGD MGI:1346030
Felis catus LY6H VGNC VGNC:81669
Canis familiaris LY6H VGNC VGNC:51776
Rattus norvegicus LY6H RGD RGD:1311896
Bos taurus LY6H VGNC VGNC:31091
Others LY6H NCBI