LYZ - lysozyme Gene

Also Known as LZM; LYZF1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4069

About LYZ

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,348,381-69,354,234 (from NCBI)

This gene has 3 transcripts (splice variants), 407 orthologues, 8 paralogues and is associated with 2 phenotypes. Biased expression in stomach (RPKM 5710.8), salivary gland (RPKM 4398.2) and 8 other tissues.

Summary

This gene encodes human lysozyme, whose natural substrate is the Bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has Antibacterial activity against a number of Bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

LYZ Products (1)

mRNA Protein Name
NM_000239.3 NP_000230.1 lysozyme C precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
23353684 GOA
Biological Process GO Annotation Evidence References Source
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
21093056 GOA
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
21093056 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
9727055 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
21805676 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LYZ Protein Structure

Lys

Lys: C-type lysozyme/alpha-lactalbumin family (19 - 146)

  • 0
  • 100
  • 148 a.a.
Protein Preferred Names Protein Names

lysozyme C

  • 1,4-beta-N-acetylmuramidase C

LYZ Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LYZ P61626 IKBKB Homo sapiens O14920
TAP
14743216
Intra
LYZ P61626 NFKBIB Homo sapiens Q15653
TAP
14743216
Intra
LYZ P61626 CFP Homo sapiens P27918
ELISA
24355864
Intra
LYZ P61626 LYZ Homo sapiens P61626
Light Scattering
23353684
Intra
LYZ P61626 LYZ Homo sapiens P61626
EM
23353684
Intra
LYZ P61626 gpmI Bacillus anthracis Q81X77
Y2H Pooling
20711500
Intra
LYZ P61626 LYZ Homo sapiens P61626
Fluorescence
23353684
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LYZ Proteins

Cat. No. Product Name Accession Purity
HY-P70390 Lysozyme C/LYZ Protein, Human (HEK293, His) P61626 (K19-V148) ≥ 95%, as determined by reducing SDS-PAGE.

LYZ Antibodies

Cat. No. Product Name Application Reactivity
HY-P80748 Lysozyme Antibody WB, IHC-P Human
HY-P85788 Lysozyme Antibody (YA5480) IHC-P, WB, ICC/IF, ELISA Human, Mouse, Rat
HY-P86037 Lysozyme Antibody (YA5729) IHC-P, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Amyloidosis, Familial Visceral

  • Ostertag Type Amyloidosis

  • German Type Amyloidosis

  • Familial Renal Amyloidosis

  • Amyloidosis Viii

  • Amyloidosis, 3 Or More Types

  • Familial Visceral Amyloidosis

  • Familial Amyloid Nephropathy

  • Hereditary Amyloid Nephropathy

  • Amyloidosis, Familial Renal

  • Amyloidosis, Systemic Nonneuropathic

  • Amyloidosis Familial Visceral

  • Amyloidosis 8

  • Amyloidosis, Ostertag Type

  • Hereditary Amyloidosis With Primary Renal Involvement

  • Hereditary Renal Amyloidosis

  • Renal Amyloidosis

  • Amyloidosis, Renal

  • Systemic Nonneuropathic Amyloidosis

  • Amyloidosis Familial Renal

  • Amyloidosis Systemic Nonneuropathic

  • Hereditary Amyloidosis With Primary Renal Involement

  • AMYL8

  • Systemic Non-Neuropathic Amyloidosis

  • Amyloid Nephropathy
Immunoglobulin Light Chain Amyloidosis

  • Al Amyloidosis

  • Primary Amyloidosis

  • Primary Systemic Amyloidosis

  • Light Chain Amyloidosis

  • Amyloidosis Al

  • Amyloidosis Primary Systemic

  • Primary Al Amyloidosis

  • Primary Systemic Al Amyloidosis

  • Systemic Al Amyloidsis

  • Systemic Al Amyloidosis

  • Light-Chain Amyloidosis

  • Alys Amyloidosis

  • Familial Amyloid Nephropathy Due To Lysozyme Variant

  • Familial Renal Amyloidosis Due To Lysozyme Variant

  • Hereditary Amyloid Nephropathy Due To Lysozyme Variant

  • Hereditary Renal Amyloidosis Due To Lysozyme Variant

  • Lysozyme Amyloidosis

  • Amyloidosis Primary

  • Immunoglobulin Deposition Disease

  • Immunoglobulinic Amyloidosis

  • Amyloid Al
Amyloidosis

  • Amyloid Disease

  • Amyloid

  • Amyloid Degeneration

  • Amyloidosis Nos

  • Amyloid Deposition

  • Amyloid Infiltration

  • Idiopathic Amyloidosis

  • Hyaloid Degeneration

  • Lardaceous Degeneration
Tuberculous Meningitis

  • Tubercular Meningitis

  • Tb Meningitis

  • Tuberculosis, Meningeal

  • Tbm

  • Meningitis Tuberculous

  • Tbm - [Tuberculous Meningitis]

  • Meningitis Due To Mycobacterium Tb

  • Caseous Meningitis

  • Tuberculous Meninges Adhesions

  • Tuberculous Leptomeningitis

  • Meningeal Tuberculosis

  • Meningeal Tb

  • Meningeal Tbc - [Tuberculosis]
Malignant Adenofibroma

  • Adenocarcinofibroma
Meningitis

  • Streptococcal Meningitis

  • Acute Streptococcal Meningitis

  • Staphylococcal Meningitis

  • Adenoviral Meningitis

  • Influenza Meningitis

  • Influenzal Meningitis

  • Meningitis Due To H. Influenzae

  • Cryptococcal Meningitis

  • Fungal Meningitis Due To Cryptococcus Neoformans

  • Cryptococcosis Meningitis

  • Cryptococcus Meningitis

  • Cryptococcal Meningoencephalitis

  • Meningitis Due To Cryptococcus

  • Mumps Virus Meningitis

  • Mumps Meningitis
Isthmus Cancer
Hereditary Amyloidosis

  • Amyloidosis Hereditary

  • Familial Amyloidosis

  • Amyloidosis Familial

  • Amyloidosis, Hereditary

  • Amyloidosis, Familial

  • Genetic Amyloidosis

  • Heredofamilial Amyloidosis
Opportunistic Bacterial Infectious Disease
Nocardiosis

  • Nocardia Infection

  • Nocardia Infections

  • Nocardia Infectious Disease

  • Lung Nocardiosis

  • Nocardiasis

  • Nocardiosis Nos
Bacterial Meningitis

  • Meningitis, Bacterial

  • Meningitis Bacterial

  • Bm - [Bacterial Meningitis]

  • Leptomeningitis Bacterial

  • Pachymeningitis Bacterial

  • Arachnoiditis Bacterial
Dental Caries

  • Dental Caries Extending Into Pulp

  • Dental Caries Of Smooth Surface

  • Dental Caries Pit And Fissure

  • Smooth Surface Dental Caries

  • Dental Decay

  • Carious Teeth

  • Dental Cavity

  • Saprodontia

  • Teeth Decayed

  • Tooth Caries

  • Tooth Decay
Anaerobic Pneumonia

  • Pneumonia Due To Anaerobes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07930 LYZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W109513 Boc-Lys(Z)-OH (DCHA) / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LYZ VGNC VGNC:74466
Canis familiaris LYZ VGNC VGNC:42901
Rattus norvegicus LYZ RGD RGD:3026
Felis catus LYZ VGNC VGNC:68114
Others LYZ NCBI