MEP1A - meprin A subunit alpha Gene

Also Known as PPHA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4224

About MEP1A

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:46,793,389-46,845,984 (from NCBI)

This gene has 4 transcripts (splice variants), 40 orthologues and 35 paralogues. Biased expression in small intestine (RPKM 216.8), duodenum (RPKM 122.1) and 1 other tissue.

Summary

Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular exosome. Part of meprin A complex. [provided by Alliance of Genome Resources, Apr 2022]

MEP1A Products (1)

mRNA Protein Name
NM_005588.3 NP_005579.2 meprin A subunit alpha precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metallodipeptidase activity IDA
IDA: Inferred from direct assay
22923609 GOA
enables metallopeptidase activity IDA
IDA: Inferred from direct assay
22923609 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9288916 GOA
Biological Process GO Annotation Evidence References Source
involved in epidermal growth factor receptor ligand maturation IDA
IDA: Inferred from direct assay
22923609 GOA
involved in signaling receptor ligand precursor processing IDA
IDA: Inferred from direct assay
22923609 GOA
Cellular Component GO Annotation Evidence References Source
part of meprin A complex IDA
IDA: Inferred from direct assay
9288916 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
22923609 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEP1A Protein Structure

Astacin

Astacin: Astacin (Peptidase family M12A) (74 - 260)

MAM

MAM: MAM domain, meprin/A5/mu (269 - 432)

MATH

MATH: MATH domain (438 - 594)

EGF

EGF: EGF-like domain (674 - 708)

  • 0
  • 200
  • 400
  • 600
  • 746 a.a.
Protein Preferred Names Protein Names

meprin A subunit alpha

  • N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha

MEP1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MEP1A Q16819 MMP9 Homo sapiens P14780
Zymography
23123160
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MEP1A Proteins

Cat. No. Product Name Accession Purity
HY-P77083 Meprin alpha/MEP1A Protein, Human (HEK293, His) Q16819/NP_005579.2 (V22-Q601) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Colorado Tick Fever

  • Mountain Tick Fever

  • Tick Fever, American Mountain

  • American Mountain Fever

  • Colorado Tick Encephalitis

  • Colorado Tick-Borne Disease

  • Mountain Fever

  • American Mountain Tick Fever

  • Colorado Tick-Borne Fever

  • Colorado Tick Fever Virus

  • Non-Exanthematous Tick Fever
Powassan Encephalitis

  • Powassan Encephalitis Virus Infection
Anisakiasis

  • Infection By Anisakis Larva

  • Anisakis Infection

  • Pseudoterranova Infection

  • Anisakiasis Due To Anisakis Simplex

  • Anisakiasis Due To Pseudoterranova Decipiens

  • Anisakis Infestation

  • Infection Due To Anisakis Larvae
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus MEP1A MGD MGI:96963
Canis familiaris MEP1A VGNC VGNC:43159
Felis catus MEP1A VGNC VGNC:102461
Bos taurus MEP1A VGNC VGNC:31388
Macaca mulatta MEP1A VGNC VGNC:74704
Rattus norvegicus MEP1A RGD RGD:3080
Others MEP1A NCBI