MME - membrane metalloendopeptidase Gene

Also Known as NEP; SFE; CD10; CALLA; CMT2T; SCA43

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4311

About MME

Cytogenetic location: 3q25.2 Genomic coordinates (GRCh38): 3:155,024,202-155,183,729 (from NCBI)

This gene has 17 transcripts (splice variants), 236 orthologues, 6 paralogues and is associated with 6 phenotypes. Biased expression in duodenum (RPKM 88.5), kidney (RPKM 83.7) and 8 other tissues.

Summary

The protein encoded by this gene is a type II Transmembrane Glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide Hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]

MME Products (7)

mRNA	Protein	Name
NM_000902.5	NP_000893.2	neprilysin isoform a
NM_001354642.2	NP_001341571.1	neprilysin isoform a
NM_001354643.1	NP_001341572.1	neprilysin isoform a
NM_001354644.1	NP_001341573.1	neprilysin isoform b
NM_007287.4	NP_009218.2	neprilysin isoform a
NM_007288.3	NP_009219.2	neprilysin isoform a
NM_007289.4	NP_009220.2	neprilysin isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cardiolipin binding	IDA IDA: Inferred from direct assay	22183801	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	8168535	GOA
enables endopeptidase activity	IGI IGI: Inferred from genetic interaction	14749444	GOA
enables endopeptidase activity	IMP IMP: Inferred from mutant phenotype	2531377	GOA
enables exopeptidase activity	IDA IDA: Inferred from direct assay	6208535	GOA
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	6208535	GOA
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	2521388	GOA
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	22183801	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17342744	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	22183801	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	8168535	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid-beta clearance	IDA IDA: Inferred from direct assay	12657655	GOA
involved in amyloid-beta clearance	IGI IGI: Inferred from genetic interaction	14749444	GOA
involved in amyloid-beta clearance by cellular catabolic process	IDA IDA: Inferred from direct assay	15100223	GOA
involved in amyloid-beta clearance by cellular catabolic process	IGI IGI: Inferred from genetic interaction	24825898	GOA
involved in bradykinin catabolic process	IDA IDA: Inferred from direct assay	6349683	GOA
involved in cellular response to UV-A	IDA IDA: Inferred from direct assay	20876573	GOA
involved in cellular response to UV-B	IDA IDA: Inferred from direct assay	20876573	GOA
involved in cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	20876573	GOA
involved in creatinine metabolic process	IMP IMP: Inferred from mutant phenotype	22024547	GOA
involved in hormone catabolic process	IDA IDA: Inferred from direct assay	6349683	GOA
involved in kidney development	IEP IEP: Inferred from expression pattern	22272689	GOA
involved in learning or memory	IGI IGI: Inferred from genetic interaction	24825898	GOA
involved in neuropeptide processing	IGI IGI: Inferred from genetic interaction	24825898	GOA
involved in positive regulation of neurogenesis	IGI IGI: Inferred from genetic interaction	24825898	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	8168535	GOA
involved in proteolysis	IGI IGI: Inferred from genetic interaction	14749444	GOA
involved in proteolysis	IMP IMP: Inferred from mutant phenotype	19057576	GOA
involved in replicative senescence	IEP IEP: Inferred from expression pattern	20876573	GOA
involved in substance P catabolic process	IDA IDA: Inferred from direct assay	6208535	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IGI IGI: Inferred from genetic interaction	14749444	GOA
located in brush border	IDA IDA: Inferred from direct assay	22272689	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20876573	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	15100223	GOA
located in early endosome	IDA IDA: Inferred from direct assay	15100223	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	15100223	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	15100223	GOA
located in neuronal cell body	IGI IGI: Inferred from genetic interaction	24825898	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20876573	GOA
located in presynapse	IGI IGI: Inferred from genetic interaction	14749444	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	15100223	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MME Protein Structure

Peptidase_M13_N

Peptidase_M13

0
200
400
600
750 a.a.

Protein Preferred Names	Protein Names
neprilysin	atriopeptidase

MME Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MME	P08473	HSPB1	Homo sapiens	P04792	Anti Bait CoIP	17342744
Intra	MME	P08473	CD9	Homo sapiens	P21926	Anti Bait CoIP	23289620
Intra	MME	P08473	HSPA1A	Homo sapiens	P08107	Anti Bait CoIP	17342744

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MME Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71757	MME Protein, Human (P.pastoris, His)	P08473 (Y52-W750)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72876	MME Protein, Human (HEK293)	P08473 (Y52-W750)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72877	MME Protein, Human (HEK293, Fc)	P08473 (Y52-W750)	≥ 95%, as determined by reducing SDS-PAGE.

MME Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81568	CD10 Antibody (YA1313)	WB, IHC-P, IP	Human, Rat
HY-P84008	CD10 Antibody (YA3705)	WB, IHC-P, FC, ELISA	Human
HY-P84008A	CD10 Antibody (YA3705)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P85080	CD10 Antibody (YA4772)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P85660	CD10 Antibody (YA5352)	ICC/IF, IHC-P	Human, Mouse, Rat
HY-P86377	CD10 Antibody (YA6069)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 43	SCA43 Spinocerebellar Ataxia Type 43
Charcot-Marie-Tooth Disease, Axonal, Type 2t	CMT2T Charcot-Marie-Tooth Disease Axonal Type 2t Charcot-Marie-Tooth Neuropathy, Type 2t Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2t Ar-Cmt2t Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2t Mme-Related Autosomal Dominant Charcot Marie Tooth Disease Type 2 Charcot-Marie-Tooth Neuropathy Type 2t Charcot-Marie-Tooth Disease Type 2t Mme-Related Autosomal Dominant Cmt2 Mme-Related Autosomal Dominant Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Disease 2t Charcot-Marie-Tooth Neuropathy Axonal Type 2t
Congenital Membranous Nephropathy Due To Fetomaternal Anti-Neutral Endopeptidase Alloimmunization	Alloimmune Neonatal Renal Disease Fmaig Fetomaternal Alloimmunization With Antenatal Glomerulopathies Neonatal Glomerulopathy Due To Neprilysin Alloimmunization Neonatal Membranous Glomerulopathy With Maternal Nep Deficiency Neonatal Membranous Glomerulopathy With Maternal Neutral Endopeptidase Deficiency
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Adenosarcoma	Mullerian Adenosarcoma
Adenomyoma
Adenofibroma
Endometrial Stromal Sarcoma	Ess Endometrial Stromal Sarcoma, High Grade Undifferentiated Endometrial Sarcoma Stromal Sarcoma Of The Corpus Uteri Sarcoma Endometrial Stromal Sarcoma, Endometrial Stromal Undifferentiated Stromal Sarcoma
Cystadenoma	Cystoma Craniopharyngioma
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Atypical Polypoid Adenomyoma
Carcinosarcoma	Mixed Tumor, Mullerian Malignant Mixed Mesodermal Tumor Malignant Mixed Mullerian Tumor Mmmt Mixed Tumor, Mesodermal Mesodermal Mixed Tumor Mixed Mesodermal Tumor Mullerian Mixed Tumor Mixed Mullerian Tumor Malignant Mixed Müllerian Tumor Mixed Müllerian Tumor Mixed Tumor Mullerian Mixed Tumor, Not Otherwise Specified
Benign Breast Phyllodes Tumor	Phyllodes Tumor Benign Cystosarcoma Phyllodes Benign Phyllodes Neoplasm Benign Phyllodes Neoplasm Of The Breast Cystosarcoma Phyllodes Phyllodes Neoplasm Phyllodes Tumor, Benign
Nephroma	Benign Nephroma
Oncocytoma	Oxyphilic Adenoma Follicular Adenoma, Oxyphilic Cell Adenoma, Oxyphilic Hurthle Cell Tumor Oncocytic Neoplasm
Ovarian Lymphoma
Bladder Lymphoma	Lymphoma Of The Urinary Bladder
Angioedema	Angioneurotic Oedema Quincke'S Edema Angioneurotic Edema Giant Urticaria
Colon Lymphoma	Colonic Lymphoma Lymphoma Of Colon
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Fallopian Tube Benign Neoplasm
Fallopian Tube Adenofibroma
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Ureteral Lymphoma	Lymphoma Of Ureter Ureter Lymphoma
Cervical Adenomyoma
Cervical Benign Neoplasm
Cellular Leiomyoma
Cervix Endometriosis	Endometriosis Of Cervix Cervical Endometriosis
Gastrointestinal Lymphoma
Retroperitoneal Lymphoma
Fallopian Tube Endometriosis	Endometriosis Of Fallopian Tube Adenomyosis Of Fallopian Tube
B-Lymphoblastic Leukemia/Lymphoma	B Lymphoblastic Leukemia/Lymphoma B-All Precursor B Lymphoblastic Lymphoma/Leukemia C-All Lymphoblastic Lymphoma, Nos Common Precursor B All Lymphoblastic B-Cell Lymphoma Pro-B All B-Precursor Lymphoma Lbl - [Lymphoblastic Lymphoma]
Kidney Osteogenic Sarcoma	Renal Osteogenic Sarcoma Kidney Extraskeletal Osteosarcoma
Congestive Heart Failure	Congestive Heart Disease Heart Failure Cardiac Failure Congestive Chf Weak Heart Heart Failure Congestive Ccf - [Congestive Cardiac Failure] Chf - [Congestive Heart Failure] Congestive Cardiac Diseases Congested Heart Failure Congestive Cardiac Failure Cardiac Anasarca Cardiac Oedema Cardiac Stasis Cardiovascular Oedema Cardiac Hydrops Congestive Failure Heart Congestion Heart Fluid Oedematous Heart
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Mixed Endometrial Stromal And Smooth Muscle Tumor	Stromomyoma Mixed Endometrial Stromal And Smooth Muscle Neoplasm
Leiomyoma	Leiomyomatous Neoplasm Leiomyomatous Tumor Leiomyomas Fibroid Tumor Uterine Fibroids
Tooth Disease	Tooth Diseases Teeth Disease Tooth Disorders
Cerebral Amyloid Angiopathy, Cst3-Related	Cerebral Amyloid Angiopathy Hereditary Cerebral Hemorrhage With Amyloidosis Hchwa Hereditary Cystatin C Amyloid Angiopathy Cerebral Amyloid Angiopathy, Familial Amyloidosis, Cerebroarterial, Icelandic Type Amyloidosis Vi Cerebral Hemorrhage, Hereditary, With Amyloidosis Cst3-Related Cerebral Amyloid Angiopathy Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant Caa, Familial Cerebral Amyloid Angiopathy, Genetic Acys Amyloidosis Cst3-Related Amyloidosis Cystatin Amyloidosis Hchwa, Icelandic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type Amyloidosis 6 AMYL6 Acys Caa Cerebral Amyloid Angiopathy Cst3-Related Cerebroarterial Amyloidosis Icelandic Type Cystatin C Amyloidosis Hccaa Hchwai Hchwa-I Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type Cerebral Amyloid Angiopathy Familial Angiopathy, Amyloid, Cerebral, Cst3-Related Hereditary Cerebral Amyloid Angiopathy, Icelandic Type Familial Cerebral Amyloid Angiopathy Cerebral Amyloid Angiopathy, Hereditary
Vaginal Adenosarcoma
Hydronephrosis	Stricture Of Ureteropelvic Junction With Hydronephrosis Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Uterine Corpus Adenosarcoma	Adenosarcoma Of Uterine Corpus Uterine Corpus Mullerian Adenosarcoma
Membranous Nephropathy	Membranous Glomerulonephritis Glomerulonephritis, Membranous Idiopathic Membranous Nephropathy Idiopathic Membranous Glomerulonephritis MBNP Membranous Nephropathy, Susceptibility To Extramembranous Glomerulonephritis Mgn Membranous Gn Primary Membranous Glomerulonephritis Primary Membranous Nephropathy Nephropathy Membranous
Cervical Carcinosarcoma	Cervical Malignant Mixed Mesodermal Mullerian Tumor Cervical Malignant Mixed Mullerian Tumor Cervical Mixed Epithelial And Mesenchymal Neoplasm
Appendix Lymphoma	Appendiceal Lymphoma
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral
Spleen Cancer	Spleen Neoplasm Splenic Neoplasm Splenic Neoplasms Malignant Splenic Tumor Malignant Tumour Of Spleen Tumor Of Spleen Malignant Neoplasm Of Spleen
Angiomyolipoma	Angiomyolipoma Of Kidney
Smooth Muscle Tumor
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Fallopian Tube Endometrioid Adenocarcinoma	Endometrioid Carcinoma Of The Fallopian Tube Fallopian Tube Endometrioid Cancer Fallopian Tube Endometrioid Neoplasm Fallopian Tube Endometrioid Tumor
Hemangioblastoma	Capillary Hemangioblastoma
Splenic Marginal Zone Lymphoma	Smzl Splenic Marginal Zone B-Cell Lymphoma
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Childhood Acute Lymphocytic Leukemia	Childhood Acute Lymphoblastic Leukemia Childhood All Pediatric Acute Lymphoblastic Leukemia Lymphoblastic Leukemia Acute Childhood
Lung Lymphoma	Pulmonary Lymphoma Lymphoma Of Lung Primary Lung Lymphoma
Heart Lymphoma	Lymphoma Of Heart Cardiac Lymphoma
Paranasal Sinus Lymphoma	Lymphoma Of Accessory Sinus Lymphoma Of Paranasal Sinus
Mucocele Of Appendix	Appendicele Mucocele Appendicular Mucocele Appendiceal Mucocele
Marginal Zone B-Cell Lymphoma	Marginal Zone Lymphoma Mzl Mucosa-Associated Lymphoid Tissue Lymphoma
Endometrial Stromal Tumor	Endometrial Stromal Neoplasm Endometrial Stromal Tumors
Gallbladder Lymphoma	Lymphoma Of The Gallbladder
Nodal Marginal Zone Lymphoma	Mucosa-Associated Lymphoid Tissue Lymphoma Monocytoid B-Cell Lymphoma
Intravenous Leiomyomatosis	Leiomyomatosis
Vaginal Endometrial Stromal Tumor
Lung Hilum Cancer	Malignant Tumor Of Lung Hilum Primary Malignant Neoplasm Of Hilus Of Lung
Hilar Lung Carcinoma
Thyroid Lymphoma
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma	Cll/Sll B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma Icdo:9823/3 Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission Small Cell B-Cell Lymphoma
Myoma	Muscle Benign Neoplasm Myomatous Neoplasm Neoplasms, Muscle Tissue Benign Neoplasm Of The Muscle Muscle Neoplasm Muscle Tissue Neoplasm Myomatous Tumor Neoplasm Of Muscle Muscle Neoplasms Myomas
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Bone Lymphoma	Lymphoma Of Bone Lymphoma Of The Bone
Cervical Adenosarcoma	Cervical Muellerian Adenosarcoma Cervical Mullerian Adenosarcoma
Inclusion Body Myositis	Ibm Sporadic Inclusion Body Myositis Inflammatory Myopathy Myositis, Inclusion Body Inflammatory Myopathies Sibm Myositis Inclusion Body Nonaka Myopathy Inclusion Body Myopathy, Autosomal Recessive Inclusion Body Myopathy, Autosomal Dominant Myositis Inclusion Body Myopathy, Sporadic
Urethra Leiomyoma	Leiomyoma Of The Urethra Urethral Leiomyoma
Breast Lymphoma	Lymphoma Of Breast Lymphoma Of The Breast Malignant Lymphoma Of Breast
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Wolffian Duct Adenocarcinoma	Cervical Mesonephric Adenocarcinoma
Salpingitis Isthmica Nodosa
Chest Wall Lymphoma	Chest Wall Cancer Lymphoma Of Chest Wall Lymphoma Of The Chest Wall Malignant Neoplasm Of Chest Wall Malignant Tumor Of Chest Wall
Cervical Polyp	Cervix Adenomatous Polyp
Clear Cell Hidradenoma	Clear Cell Myoepithelioma Eccrine Acrospiroma
Sarcomatoid Renal Cell Carcinoma	Renal Cell Carcinoma, Spindle Cell
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Breast Myofibroblastoma
Breast Fibroadenoma	Fibroadenoma Fibroadenoma Of Breast Juvenile Fibroadenoma Of Breast Cellular Fibroadenoma Complex Fibroadenoma Of Breast Juvenile Fibroadenoma Fibroadenoma Nos Fibroadenoma Unspecified Site
Gastric Lymphoma	Familial Primary Gastric Lymphoma Lymphoma Of The Stomach Primary Gastric Lymphoma
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Hairy Cell Leukemia	Hcl-V Hairy Cell Leukemia Variant Hairy Cell Leukaemia Variant Hcl Leukemic Reticuloendotheliosis Leukemic Reticuloendotheliosis Variant Prolymphocytic Variant Of Hcl Prolymphocytic Variant Of Hairy Cell Leukemia Leukemia Hairy Cell Leukemia, Hairy Cell Leukaemic Reticuloendotheliosis Lre - [Leukemic Reticuloendotheliosis] Hairy-Cell Leukaemia, Nos Hcl - [Hairy Cell Leukaemia] Hairy-Cell Leukaemia Without Mention Of Remission
Epithelioid Type Angiomyolipoma	Epithelioid Angiomyolipoma
Adult Lymphoma
Central Nervous System Hematologic Cancer	Cns Hematopoietic Tumor Hematopoietic Neoplasm Of Central Nervous System Central Nervous System Hematopoietic Neoplasm
Central Nervous System Lymphoma	Microglioma Primary Cns Lymphoma Cns Lymphoma Primary Central Nervous System Lymphoma
Nephrogenic Adenoma	Nephrogenic Metaplasia
Composite Lymphoma	Composite Hodgkin And Non-Hodgkin Lymphoma
Angioimmunoblastic T-Cell Lymphoma	Immunoblastic Lymphadenopathy Lymphogranulomatosis X T-Cell Lymphoma, Aild Type Aitl Ailt Angioimmunoblastic Lymphadenopathy Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia] Angioimmunoblastic Lymphoma
Tubular Adenocarcinoma	Tubular Carcinoma Adenocarcinoma Tubular Adenocarcinoma, Tubular
Childhood Lymphoma	Pediatric Lymphoma
Systolic Heart Failure	Heart Failure, Systolic
Fallopian Tube Leiomyoma
Uterine Inversion	Inversion Of Uterus During Delivery
Renal Oncocytoma	Oncocytoma, Renal Oncocytoma Of Kidney Renal Epithelial Oncocytic Tumor Oncocytoma Kidney Oncocytoma Renal Kidney Oncocytoma
Lymphoplasmacytic Lymphoma	Waldenstrom Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic Waldenström Macroglobulinaemia Waldenström Macroglobulinaemia Without Mention Of Remission Idiopathic Macroglobulinaemia Primary Macroglobulinaemia
Xanthogranulomatous Pyelonephritis	Pyelonephritis, Xanthogranulomatous
Metanephric Adenoma
Testicular Lymphoma	Malignant Lymphoma Of Testis Lymphoma Of The Testis
Renal Adenoma	Renal Cell Adenoma
Aids Phobia
Cecum Lymphoma	Cecal Lymphoma
Gallbladder Carcinoma In Situ
Perivascular Epithelioid Cell Tumor	Pecoma Perivascular Epithelioid Cell Neoplasms Neoplasm With Perivascular Epithelioid Cell Differentiation
Kidney Benign Neoplasm	Renal And Ureteral Tumor Benign Kidney Neoplasm
Endometrial Stromal Nodule
Subareolar Duct Papillomatosis	Adenoma Of The Nipple
Nipple Benign Neoplasm	Tumor Of Nipple
High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit	Hgbl-Dh/Th High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement
Invasive Malignant Thymoma	Infiltrating Thymoma Thymoma Malignant Invasive Invasive Thymoma And Thymic Carcinoma
Monoclonal Paraproteinemia	Monoclonal Paraproteinaemia
B-Cell Prolymphocytic Leukemia	B Cell Prolymphocytic Leukemia Prolymphocytic Leukemia, B-Cell Type B-Pll Doid:0081041 Leukemia, Prolymphocytic, B-Cell Pll- [Prolymphocytic Leukaemia] Prolymphocytic Leukaemia Prolymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission
Nephrogenic Adenoma Of Urinary Bladder	Nephrogenic Adenoma Of The Urinary Bladder
Prostate Lymphoma	Lymphoma Of Prostate
Liver Lymphoma	Lymphoma Of Liver
Mitral Valve Insufficiency	Mitral Regurgitation Congenital Insufficiency Of Mitral Valve Congenital Mitral Insufficiency Congenital Mitral Regurgitation Mitral Valve Incompetence Mitral Valve Regurgitation Mr - [Mitral Regurgitation] Mi - [Mitral Incompetence] Mitral Valve Annular Incompetency Congenital Mitral Valve Incompetence Congenital Mitral Valve Insufficiency Congenital Mitral Valve Regurgitation Congenital Mitral Incompetence
Tracheal Lymphoma	Lymphoma Of The Trachea Lymphoma Of Trachea
Breast Leiomyoma
Balloon Cell Malignant Melanoma
Mixed Cell Type Cancer	Malignant Mixed Neoplasm Malignant Mixed Tumor Mixed Neoplasm Mixed Tumor, Malignant Malignant Mixed Cancer Mixed Tumor Malignant Mixed Tumor, Not Otherwise Specified Mixed Salivary Gland Tumor Mixed Tumor, Not Otherwise Specified
Cervix Erosion	Erosion Of Cervix Uterine Cervical Erosion
Small Intestine Lymphoma	Small Intestinal Lymphoma
Central Nervous System Leukemia	Leukemia Of The Cns
Bladder Clear Cell Adenocarcinoma	Bladder Mesonephric Adenocarcinoma Clear Cell Adenocarcinoma Of Bladder
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Diffuse Large B-Cell Lymphoma Activated B-Cell Type	Dlbcl Abc Type
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Breast Malignant Phyllodes Tumor	Malignant Cystosarcoma Phyllodes Malignant Phyllodes Tumor Of Breast Malignant Phyllodes Tumour Of Breast Phyllodes Breast Tumor Phyllodes Tumor Of The Breast Breast Malignant Phyllodes Tumour Malignant Mammary Phyllodes Tumor Malignant Mammary Phyllodes Tumour Malignant Phyllodes Neoplasm Malignant Phyllodes Tumor Malignant Phyllodes Tumour Phyllodes Breast Neoplasm Phyllodes Breast Tumour Phyllodes Tumor, Malignant Cystosarcoma Phyllodes Cystosarcoma Phyllodes Of The Breast Phylloides Tumor Malignant Breast Phyllodes Tumor Breast Phyllodes Tumor Phyllodes Tumor Malignant Phyllodes Cystosarcoma Of Unspecified Site
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Cutaneous Fibrous Histiocytoma	Dermatofibroma Fibrohistiocytic Tumor Benign Cutaneous Fibrous Histiocytoma Fibrous Histiocytoma Of Skin Fibrous Xanthoma Of Skin Pleomorphic Fibroma Sclerosing Angioma Sclerosing Angioma Of Skin Fibrous Histiocytoma
Ovarian Sex-Cord Stromal Tumor	Ovarian Sex Cord Tumor With Annular Tubules Ovarian Sex Cord-Stromal Tumor Stromal Tumor Of Ovary
Kidney Cortex Disease
Collecting Duct Carcinoma	Kidney Medullary Carcinoma Renal Medullary Carcinoma Bdc Bellini Carcinoma Bellini Duct Carcinoma Cdc Collecting Duct Carcinoma Of The Kidney Renal Cell Adenocarcinoma Carcinoma Of Renal Collecting Duct Renal Carcinoma, Collecting Duct Type Renal Cell Carcinoma Bellini'S Duct Carcinoma Renal Collecting Duct Carcinoma Adenocarcinoma Of Kidney
Reproductive Organ Benign Neoplasm
Perivascular Tumor	Malignant Perivascular Cancer
Plasmablastic Lymphoma	Pbl Immunoblastic Large-Cell Lymphoma
Intrahepatic Bile Duct Adenoma	Adenoma Of Intrahepatic Bile Duct Adenoma Of The Intrahepatic Bile Duct
Vaginal Endometrial Stromal Sarcoma
Gray Zone Lymphoma	B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Eye Lymphoma	Malignant Lymphoma Of Eye Lymphoma Of Eye
Vagina Sarcoma	Sarcoma Of The Vagina Vaginal Sarcoma
Cervical Serous Adenocarcinoma
Sarcomatoid Squamous Cell Skin Carcinoma	Spindle Cell Squamous Cell Carcinoma Spindle Cell Squamous Cell Carcinoma Spindle Cell Squamous Cell Skin Carcinoma Spindle Cell Squamous Carcinoma Of Skin Squamous Cell Carcinoma, Sarcomatoid
Fibrous Histiocytoma	Benign Fibrous Histiocytoma Histiocytoma, Benign Fibrous Fibroxanthoma Histiocytoma Fibrous
Mitral Valve Disease	Chronic Rheumatic Mitral Valve Rheumatic Mitral Insufficiency Disease Of Mitral Valve Mitral Rh Valve Dis. Rheumatic Disease Of Mitral Valve Rheumatic Mitral Valve Changes Rheumatic Mitral Valve Incompetence Rheumatic Mitral Valve Regurgitation Abnormality Of The Mitral Valve Diseases Of Mitral Valve Rheumatic Mitral Regurgitation
Mature B-Cell Neoplasm	Mature B-Cell Lymphocytic Neoplasm Neoplasm Of Mature B-Cells Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Sternum Cancer	Malignant Sternal Neoplasm Neoplasm Of Sternum
Sternum Lymphoma	Lymphoma Of Sternum Lymphoma Of The Sternum
Uterine Benign Neoplasm
Cutaneous Leiomyosarcoma	Leiomyosarcoma Of The Skin
Breast Metaplastic Carcinoma	Metaplastic Carcinoma Of The Breast Metaplastic Breast Carcinoma Metaplastic Carcinoma Of Breast Metaplastic Breast Cancer
Epithelioid Leiomyosarcoma	Leiomyosarcoma Epithelioid Leiomyosarcoma, Epithelioid
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Hidradenoma	Adenoma, Sweat Gland Hidradenoma Of Skin Sweat Gland Adenoma Syringoadenoma Eccrine Acrospiroma Benign Neoplasm Of Sweat Gland
Intraocular Lymphoma	Primary Intraocular Lymphoma Piol Primary Intraocular Non-Hodgkin Lymphoma Primary Intraocular Non-Hodgkin Malignant Lymphoma
Extramedullary Plasmacytoma	Extraosseous Plasmacytoma Plasmacytoma, Extramedullary
Glandular Cystitis	Cystitis Glandularis
Adult Type Testicular Granulosa Cell Tumor
Pancreatoblastoma
Clear Cell Adenocarcinoma	Mesonephroma Water-Clear Cell Adenocarcinoma Adenocarcinoma, Clear Cell Malignant Mesonephroma Mesonephroid Clear Cell Carcinoma Mesonephroma, Malignant Water-Clear Cell Carcinoma Wolffian Duct Neoplasm Adenocarcinoma Clear Cell Mesonephric Tumor
Null-Cell Leukemia	Null Cell Acute Lymphoblastic Leukemia Null Cell Acute Lymphoblastic Leukaemia Null-Cell Leukaemia
Thoracic Benign Neoplasm	Benign Neoplasm Of Thorax
Mature T-Cell And Nk-Cell Lymphoma	Mature T-Cell And Natural Killer Cell Lymphoma Nk-T Cell Lymphoma
Sweat Gland Benign Neoplasm	Neoplasm Of Sweat Gland Sweat Gland Tumor Tumor Of The Sweat Gland Sweat Gland Neoplasms Sweat Gland Neoplasm
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Acute Biphenotypic Leukemia	Mixed Phenotype Acute Leukemia Acute Leukemia Of Ambiguous Lineage Acute Undifferentiated Leukemia Acute Leukemia Of Indeterminate Lineage Hybrid Acute Leukemia Mixed Lineage Acute Leukemia All With Myeloid Markers Aml With Lymphoid Markers Acute Leukemia Of Undetermined Lineage Bal Biphenotypic Acute Leukemia Undifferentiated Acute Leukemia Mpal Acute Myeloid Leukemia, Minimal Differentiation, Fab M0 Leukemia, Biphenotypic, Acute
Pleural Empyema	Empyema Pyothorax Empyema, Pleural Abscess Of Pleural Cavity Abscess Of Thorax Empyema Of Pleura Empyema Of Pleura Without Fistula Empyema With Fistula Empyema With No Fistula Empyema With Pleural Fistula Empyema Without Mention Of Fistula Empyema, Chest Lung Empyema Pleural Empyema With Fistula Pleural Empyema With No Fistula Purulent Pleurisy Purulent Pleuritis Thorax Abscess Pyopneumothorax
Breast Sarcoma	Sarcoma Of Breast
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Epididymis Adenocarcinoma	Adenocarcinoma Of The Epididymis
Orbital Cancer	Malignant Neoplasm Of Orbit Orbital Tumor Orbital Neoplasms Neoplasm Of Orbit Proper Orbit Cancer Primary Malignant Neoplasm Of Orbit Intraorbital Cancer
Epiglottis Neoplasm	Neoplasm Of Epiglottis Epiglottic Tumor Epiglottic Carcinoma
Breast Benign Neoplasm	Benign Tumour Of Breast Benign Neoplasm Of Female Breast
Uterine Sarcoma	Sarcoma Of The Uterus Uterine Corpus Sarcoma
Cystadenofibroma
Wolffian Duct Adenoma	Benign Mesonephroma Mesonephric Adenoma Mesonephroma, Benign Fatwo Female Adnexal Tumor Of Probable Wolffian Origin Wat Wolffian Adenoma Wolffian Adnexal Tumor Wolffian Tumor
Chronic Pyelonephritis
Intraductal Breast Benign Neoplasm
Microcystic Adenoma	Adenoma Microcystic Adenoma, Microcystic
Orbital Disease	Orbit Orbital Diseases
Epididymal Neoplasm	Neoplasm Of Epididymis
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Epididymis Cancer	Malignant Tumor Of Epididymis Malignant Epididymal Tumor Malignant Neoplasm Of Epididymis Neoplasm Of Epididymis
Urethral Benign Neoplasm	Urethral Neoplasms Neoplasm Of Urethra Neoplasm. Urethra Urethral Neoplasm Urethral Carcinoma Malignant Neoplasm Of Urethra
Splenic Disease	Splenic Diseases Dyssplenism Spleen Disease Abnormality Of The Spleen Spleen Diseases
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Plasma Protein Metabolism Disease
Ovarian Mixed Germ Cell Neoplasm	Mixed Germ Cell Tumor Of Ovary Ovarian Mixed Germ Cell Tumor
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Vulvar Leiomyoma
Adult Acute Lymphocytic Leukemia	Adult Acute Lymphoid Leukemia Adult All
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Diastolic Heart Failure	Heart Failure, Diastolic
Mucinous Tubular And Spindle Renal Cell Carcinoma	Mucinous Tubular And Spindle Cell Renal Carcinoma
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Tricuspid Valve Insufficiency	Tricuspid Regurgitation Tricuspid Valve Regurgitation Tricuspid Incompetence Tr - [Tricuspid Regurgitation] Tricuspid Valve Incompetency Tricuspid Valve Annular Incompetency
Vaginal Carcinosarcoma	Malignant Vaginal Mixed Epithelial And Mesenchymal Tumor Vaginal Malignant Mixed Mesodermal Tumor Vaginal Malignant Mixed Mullerian Tumor Vaginal Mixed Epithelial And Mesenchymal Tumor
Rhabdomyosarcoma
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Pacinian Tumor	Pacinian Neurofibroma
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Vaginal Cancer	Malignant Neoplasm Of Vagina Vaginal Neoplasms Malignant Tumor Of Vagina Malignant Vaginal Tumor Neoplasm Of Vagina Vagina Neoplasm Vaginal Tumor Vaginal Carcinoma Vaginal Malignant Epithelial Tumor Vaginal Neoplasm Malignant Vaginal Neoplasm Vagina Carcinoma Vaginal Neoplasia Cancer Of Vagina Malignant Tumour Of Vagina Carcinoma Of Vagina Primary Malignant Neoplasm Of Vagina Vagina Wall Cancer Vaginal Wall Cancer
Tricuspid Valve Disease	Rheumatic Tricuspid Valve Disease Disease Of Tricuspid Valve Rh. Tricuspid Valve Disease Rheumatic Disease Of Tricuspid Valve Tricuspid Disease Tricuspid Valve Disorder
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Benign Breast Adenomyoepithelioma	Benign Adenomyoepithelioma Of The Breast
Chromophobe Renal Cell Carcinoma	Chromophobe Adenocarcinoma Chromophobe Carcinoma Of Kidney Kidney Chromophobe Renal Cell Carcinoma, Chromophobe Cell Crcc Chrcc Chromophobe Renal Cell Adenocarcinoma Chromophobe Renal Carcinoma Chromophobe Carcinoma
Chromophil Adenoma Of The Kidney	Papillary Adenoma Of The Kidney
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Female Urethral Cancer	Female Urethral Malignant Neoplasm
Mixed Epithelial Stromal Tumour
Sclerosing Hepatic Carcinoma	Sclerosing Hepatocellular Carcinoma
Thyrotoxic Exophthalmos
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Lymphatic System Cancer
Baastrup'S Syndrome	Kissing Spine Baastrup Syndrome Kissing Spine, Site Unspecified Osteoarthrosis Interspinalis Overriding Of Dorsal Spinous Processes Localised Idiopathic Skeletal Hyperostosis Baastrup Disease
Sigmoid Disease	Sigmoid Diseases
Nasal Cavity Olfactory Neuroblastoma	Olfactory Neuroblastoma Of The Nasal Cavity
Lymphatic System Disease	Lymphatic Diseases Adenopathy Lymphatic Disease Disease Of Lympoid System Disorder Of Lymph Node And Lymphatics Disorder Of Lymphatic System Disorder Of Lymphoid System Lymphangiopathy Lymphatic Disorder Lympoid System Disease Abnormality Of The Lymphatic System
Nephrogenic Adenoma Of The Urethra	Nephrogenic Adenoma Of Urethra
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Leukocyte Disease	Leukocyte Disorders
Uterus Perivascular Epithelioid Cell Tumor	Uterine Corpus Pecoma
Pancytopenia
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Heart Conduction Disease	Conduction Disorder Of The Heart Heart Rhythm Disease
Fallopian Tube Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of The Fallopian Tube
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-165037	1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol		/	Phase 3

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08513	MME Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08522	MMP12 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08523	Mmp12 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08524	Mmp12 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS17321	Mme Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23776	Mme Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MME	VGNC	VGNC:68278
Canis familiaris	MME	VGNC	VGNC:43271
Macaca mulatta	MME	VGNC	VGNC:74886
Rattus norvegicus	MME	RGD	RGD:3098
Bos taurus	MME	VGNC	VGNC:31514
Mus musculus	MME	MGD	MGI:97004
Others	MME	NCBI