FTO - FTO alpha-ketoglutarate dependent dioxygenase Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 478125

About FTO

Primary_assembly 2: 62,226,376-62,622,690 reverse strand.ROS_Cfam_1.0:CM025101.1

This gene has 9 transcripts (splice variants) and 202 orthologues.

FTO Products (8)

mRNA Protein Name
XM_038659341.1 XP_038515269.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X6
XM_038659339.1 XP_038515267.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X4
XM_038659342.1 XP_038515270.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X7
XM_038659338.1 XP_038515266.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X3
XM_038659337.1 XP_038515265.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X2
XM_038659343.1 XP_038515271.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X8
XM_038659340.1 XP_038515268.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X5
XM_038659336.1 XP_038515264.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

FTO Protein Structure

FTO_NTD

FTO_NTD: pfam12933 (80 - 368)

FTO_CTD

FTO_CTD: cl15176 (372 - 541)

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  • 549 a.a.
Protein Preferred Names Protein Names

alpha-ketoglutarate-dependent dioxygenase FTO

  • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

  • U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO

  • fat mass and obesity-associated protein

  • m6A(m)-demethylase FTO

  • mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

  • mRNA N(6)-methyladenosine demethylase FTO

  • tRNA N1-methyl adenine demethylase FTO

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14280 Entacapone Inhibitor 99.97% Yes
HY-B1320 Meclofenamic acid sodium Inhibitor 99.89% Unkown
HY-117275 Meclofenamic acid Inhibitor 99.66% Unkown
HY-101082 N6,2′-O-Dimethyladenosine Inhibitor 99.87% Unkown
HY-14280R Entacapone (Standard) Inhibitor 99.24% Unkown
HY-117275A Meclofenamic acid sodium hydrate Inhibitor / Unkown
HY-14280A Entacapone sodium salt Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (39)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-127103 FB23-2 Inducer 99.93% Unkown
HY-137187 FB23 98.88% Unkown
HY-W074785 Carboxyl diazirine alkyne 98.0% Unkown
HY-N6769 Radicicol Inhibitor 99.96% Unkown
HY-129079 TFMB-(R)-2-HG Inhibitor 98.26% Unkown
HY-172158 ALKBH5-IN-5 99.66% Unkown
HY-149334 ZLD115 Inhibitor 99.87% Unkown
HY-173020 W23-1006 97.15% Unkown
HY-138843A FTO-IN-1 TFA 98.06% Unkown
HY-151106 FTO-IN-8 Inhibitor 95.04% Unkown
HY-RS05136 FTO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149145 Ena15 ≥99.0% Unkown
HY-174979 Dac590 96.15% Unkown
HY-145238 FTO-IN-6 98.94% Unkown
HY-147011 FTO-IN-7 Inhibitor 99.22% Unkown
HY-W588293 3-Methylthymidine 99.68% Unkown
HY-117426 MO-I-500 Inhibitor 99.10% Unkown
HY-132865 FTO-IN-3 99.79% Unkown
HY-14280S Entacapone-d10 Inhibitor 98.6% Unkown
HY-168878 EP652 Inhibitor / Unkown
HY-175885 PROTAC FTO degrader 1 / Unkown
HY-131871 Ethyl LipotF Inhibitor 99.25% Unkown
HY-RS05137 Fto Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117275S Meclofenamic acid-d4 Inhibitor / Unkown
HY-117275S1 Meclofenamic acid-13C6 Inhibitor / Unkown
HY-132863 FTO-IN-2 / Unkown
HY-138843 FTO-IN-1 / Unkown
HY-139820 FTO-IN-4 / Unkown
HY-139821 FTO-IN-5 / Unkown
HY-156405 FTO-IN-10 / Unkown
HY-168483 FTO-IN-13 / Unkown
HY-172399 FTO-IN-14 / Unkown
HY-175886 FTO ligand-1 / Unkown
HY-179266 FTO-IN-15 Inhibitor / Unkown
HY-179267 FTO-IN-16 / Unkown
HY-183325 FTO-IN-17 Inhibitor / Unkown
HY-N10340 Clausine E Inhibitor / Unkown
HY-RS05138 Fto Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W026109 FTO-IN-12 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens FTO NCBI NCBI:79068