FTO - FTO alpha-ketoglutarate dependent dioxygenase Gene

Homo sapiens

Also known as GDFD; ALKBH9; BMIQ14

Gene ID: 79068 | Gene type: protein coding

About FTO

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:53,703,963-54,121,941 (from NCBI)

This gene has 23 transcripts (splice variants), 202 orthologues and is associated with 4 phenotypes. Ubiquitous expression in brain (RPKM 7.3), adrenal (RPKM 4.2) and 25 other tissues.

Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

FTO Products(25)

mRNA	Protein	Name
XM_011523316.4	XP_011521618.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X6
NM_001363896.1	NP_001350825.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 4
NM_001363905.1	NP_001350834.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 11
XR_007064911.1
NR_156761.1
NM_001363894.1	NP_001350823.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 1
XM_017023654.3	XP_016879143.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X1
XM_047434607.1	XP_047290563.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X3
NM_001363898.1	NP_001350827.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 6
NM_001080432.3	NP_001073901.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 3
NM_001363900.1	NP_001350829.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 8
XM_011523315.4	XP_011521617.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X5
XM_017023656.3	XP_016879145.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X7
NM_001363901.1	NP_001350830.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 9
XM_047434606.1	XP_047290562.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X2
XM_047434609.1	XP_047290565.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X8
NM_001363891.1	NP_001350820.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 2
XM_011523314.4	XP_011521616.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X4
XM_024450437.2	XP_024306205.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X9
NM_001363903.1	NP_001350832.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 10
NM_001363988.1	NP_001350917.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 12
NM_001363897.1	NP_001350826.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 5
NM_001363899.1	NP_001350828.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 7
XM_017023657.3	XP_016879146.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X8
XM_047434608.1	XP_047290564.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X5

FTO Protein Structure

FTO_NTD

FTO_CTD

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

alpha-ketoglutarate-dependent dioxygenase FTO

AlkB homolog 9	U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO	fat mass and obesity associated
fat mass and obesity-associated protein	m6A(m)-demethylase FTO
mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO	mRNA N(6)-methyladenosine demethylase FTO
tRNA N1-methyl adenine demethylase FTO

Related Diseases

Diseases

Alias

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Growth Retardation, Developmental Delay, And Facial Dysmorphism

Lethal Polymalformative Syndrome, Boissel Type	Growth Retardation, Developmental Delay, Coarse Facies, And Early Death
GDFD	Growth Retardation, Developmental Delay, Facial Dysmorphism
Growth Retardation Developmental Delay Coarse Facies Early Death	Lethal Polymalformative Syndrome Boissel Type

Acquired Metabolic Disease

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Body Mass Index Quantitative Trait Locus 14

Obesity	BMIQ14
Obesity, Susceptibility To	Obesity, Susceptibility To, Bmiq14
Obesity Bmiq14	{Obesity, Susceptibility To, Bmiq14}

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Overnutrition

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Diabetes Mellitus

Diabetes

Glucose Intolerance

Glucose: Intolerance	Glucose: Malabsorption
Malabsorption Of Glucose	Impaired Glucose Tolerance

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Cervix Carcinoma

Cancer Of Cervix	Carcinoma Of Cervix
Carcinoma Cervix Uteri	Carcinoma Of The Cervix Uteri

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Leukemia, Myeloid, Acute	Acute Myeloid Leukemia, Somatic
Leukemia, Acute Myeloid, Somatic	Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic
Acute Myeloblastic Leukaemia	Acute Myelogenous Leukaemia
Aml - Acute Myeloid Leukemia	Acute Myeloid Leukemia With Cebpa Somatic Mutations
Aml With Cebpa Somatic Mutations	Inherited Acute Myeloid Leukemia
Familial Aml	Inherited Aml
Pure Familial Aml	Pure Familial Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia	Therapy-Related Aml And Myelodysplastic Syndrome
Acute Myeloid Leukemia, Secondary	Acute Non-Lymphoblastic Leukemia
Acute Non-Lymphocytic Leukemia	Acute Biphenotypic Leukemia
Acute Undifferentiated Leukemia	Acute Myeloblastic Leukaemia With Multilineage Dysplasia
Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission	Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Morbid Obesity Due To Leptin Deficiency	Obesity Morbid
Leptin Dysfunction	Leptin

Adult Spinal Cord Glioblastoma Multiforme

Glioblastoma Multiforme Of Spinal Cord

Adult Spinal Cord Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14280	Entacapone	Inhibitor	99.92%	Yes
HY-B1320	Meclofenamic acid sodium	Inhibitor	99.86%	Unkown
HY-101082	N6,2′-O-Dimethyladenosine	Inhibitor	99.93%	Unkown
HY-117275	Meclofenamic acid	Inhibitor	98.60%	Unkown
HY-117275A	Meclofenamic acid sodium hydrate	Inhibitor	/	Unkown
HY-14280R	Entacapone (Standard)	Inhibitor	/	Unkown
HY-14280A	Entacapone sodium salt	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-127103	FB23-2	Inducer	99.93%	Unkown
HY-137187	FB23		98.66%	Unkown
HY-N6769	Radicicol	Inhibitor	99.63%	Unkown
HY-151106	FTO-IN-8	Inhibitor	98.03%	Unkown
HY-145238	FTO-IN-6		98.94%	Unkown
HY-132865	FTO-IN-3		99.79%	Unkown
HY-149334	ZLD115	Inhibitor	99.24%	Unkown
HY-147011	FTO-IN-7	Inhibitor	99.22%	Unkown
HY-138843A	FTO-IN-1 TFA		98.04%	Unkown
HY-14280S	Entacapone-d10	Inhibitor	≥98.0%	Unkown
HY-RS05137	Fto Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-117275S	Meclofenamic acid-d4	Inhibitor	/	Unkown
HY-117275S1	Meclofenamic acid-13C6	Inhibitor	/	Unkown
HY-117426	MO-I-500	Inhibitor	/	Unkown
HY-132863	FTO-IN-2		/	Unkown
HY-138843	FTO-IN-1		/	Unkown
HY-139820	FTO-IN-4		/	Unkown
HY-139821	FTO-IN-5		/	Unkown
HY-156405	FTO-IN-10		/	Unkown
HY-N10340	Clausine E	Inhibitor	/	Unkown
HY-RS05136	FTO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05138	Fto Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-131871	Ethyl LipotF	Inhibitor	/	Unkown
HY-W588293	3-Methylthymidine		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FTO	VGNC	VGNC:29138
Canis familiaris	FTO	VGNC	VGNC:41003
Rattus norvegicus	FTO	RGD	RGD:1305121
Felis catus	FTO	VGNC	VGNC:62384
Macaca mulatta	FTO	VGNC	VGNC:72772
Mus musculus	FTO	MGD	MGI:1347093
Others	FTO	NCBI

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