FTO - FTO alpha-ketoglutarate dependent dioxygenase Gene

Also Known as GDFD; ALKBH9; BMIQ14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79068

About FTO

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:53,703,963-54,121,941 (from NCBI)

This gene has 23 transcripts (splice variants), 202 orthologues and is associated with 4 phenotypes. Ubiquitous expression in brain (RPKM 7.3), adrenal (RPKM 4.2) and 25 other tissues.

Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron Enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

FTO Products (25)

mRNA	Protein	Name
XM_011523316.4	XP_011521618.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X6
NM_001363896.1	NP_001350825.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 4
NM_001363905.1	NP_001350834.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 11
XR_007064911.1
NR_156761.1
NM_001363894.1	NP_001350823.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 1
XM_017023654.3	XP_016879143.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X1
XM_047434607.1	XP_047290563.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X3
NM_001363898.1	NP_001350827.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 6
NM_001080432.3	NP_001073901.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 3
NM_001363900.1	NP_001350829.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 8
XM_011523315.4	XP_011521617.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X5
XM_017023656.3	XP_016879145.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X7
NM_001363901.1	NP_001350830.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 9
XM_047434606.1	XP_047290562.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X2
XM_047434609.1	XP_047290565.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X8
NM_001363891.1	NP_001350820.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 2
XM_011523314.4	XP_011521616.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X4
XM_024450437.2	XP_024306205.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X9
NM_001363903.1	NP_001350832.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 10
NM_001363988.1	NP_001350917.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 12
NM_001363897.1	NP_001350826.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 5
NM_001363899.1	NP_001350828.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform 7
XM_017023657.3	XP_016879146.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X8
XM_047434608.1	XP_047290564.1	alpha-ketoglutarate-dependent dioxygenase FTO isoform X5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables broad specificity oxidative DNA demethylase activity	IDA IDA: Inferred from direct assay	18775698	GOA
enables ferrous iron binding	IDA IDA: Inferred from direct assay	20376003	GOA
enables mRNA N6-methyladenosine dioxygenase activity	IDA IDA: Inferred from direct assay	25452335	GOA
enables mRNA N6-methyladenosine dioxygenase activity	IMP IMP: Inferred from mutant phenotype	26458103	GOA
enables oxidative RNA demethylase activity	IDA IDA: Inferred from direct assay	18775698	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables tRNA demethylase activity	IDA IDA: Inferred from direct assay	30197295	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA alkylation repair	IDA IDA: Inferred from direct assay	18775698	GOA
involved in RNA repair	IDA IDA: Inferred from direct assay	18775698	GOA
involved in mRNA destabilization	IDA IDA: Inferred from direct assay	28002401	GOA
involved in regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	26287746	GOA
involved in regulation of lipid storage	IMP IMP: Inferred from mutant phenotype	26287746	GOA
involved in snRNA processing	IDA IDA: Inferred from direct assay	30197295	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28002401	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	22002720	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26458103	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FTO Protein Structure

FTO_NTD

FTO_CTD

0
100
200
300
400
505 a.a.

Protein Preferred Names	Protein Names
alpha-ketoglutarate-dependent dioxygenase FTO	AlkB homolog 9 U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO fat mass and obesity associated fat mass and obesity-associated protein m6A(m)-demethylase FTO mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO mRNA N(6)-methyladenosine demethylase FTO tRNA N1-methyl adenine demethylase FTO

FTO Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80680	FTO Antibody (YA424)	WB, IHC-P	Human
HY-P80680A	FTO Antibody (YA424)(PBS only)	WB, IHC-P	Human
HY-P86495	FTO Antibody (YA6187)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Growth Retardation, Developmental Delay, And Facial Dysmorphism	Lethal Polymalformative Syndrome, Boissel Type Growth Retardation, Developmental Delay, Coarse Facies, And Early Death GDFD Growth Retardation, Developmental Delay, Facial Dysmorphism Growth Retardation Developmental Delay Coarse Facies Early Death Lethal Polymalformative Syndrome Boissel Type
Acquired Metabolic Disease
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Body Mass Index Quantitative Trait Locus 14	Obesity BMIQ14 Obesity, Susceptibility To Obesity, Susceptibility To, Bmiq14 Obesity Bmiq14 {Obesity, Susceptibility To, Bmiq14}
Eating Disorder	Eating Disorders Feeding And Eating Disorders
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Overnutrition
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Diabetes Mellitus	Diabetes
Glucose Intolerance	Glucose: Intolerance Glucose: Malabsorption Malabsorption Of Glucose Impaired Glucose Tolerance
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Cervix Carcinoma	Cancer Of Cervix Carcinoma Of Cervix Carcinoma Cervix Uteri Carcinoma Of The Cervix Uteri
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction Leptin
Adult Spinal Cord Glioblastoma Multiforme	Glioblastoma Multiforme Of Spinal Cord Adult Spinal Cord Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14280	Entacapone	Inhibitor	99.97%	Yes
HY-B1320	Meclofenamic acid sodium	Inhibitor	99.89%	Unkown
HY-117275	Meclofenamic acid	Inhibitor	99.66%	Unkown
HY-101082	N6,2′-O-Dimethyladenosine	Inhibitor	99.87%	Unkown
HY-14280R	Entacapone (Standard)	Inhibitor	99.24%	Unkown
HY-117275A	Meclofenamic acid sodium hydrate	Inhibitor	99.83%	Unkown
HY-14280A	Entacapone sodium salt	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (39)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-127103	FB23-2	Inducer	99.93%	Unkown
HY-137187	FB23		98.88%	Unkown
HY-W074785	Carboxyl diazirine alkyne		98.0%	Unkown
HY-N6769	Radicicol	Inhibitor	99.96%	Unkown
HY-129079	TFMB-(R)-2-HG	Inhibitor	98.26%	Unkown
HY-172158	ALKBH5-IN-5		99.66%	Unkown
HY-149334	ZLD115	Inhibitor	99.87%	Unkown
HY-173020	W23-1006		97.15%	Unkown
HY-138843A	FTO-IN-1 TFA		98.06%	Unkown
HY-151106	FTO-IN-8	Inhibitor	95.04%	Unkown
HY-RS05136	FTO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-149145	Ena15		≥99.0%	Unkown
HY-174979	Dac590		96.15%	Unkown
HY-145238	FTO-IN-6		98.94%	Unkown
HY-147011	FTO-IN-7	Inhibitor	99.22%	Unkown
HY-W588293	3-Methylthymidine		99.68%	Unkown
HY-117426	MO-I-500	Inhibitor	99.10%	Unkown
HY-132865	FTO-IN-3		99.79%	Unkown
HY-14280S	Entacapone-d10	Inhibitor	98.6%	Unkown
HY-168878	EP652	Inhibitor	/	Unkown
HY-175885	PROTAC FTO degrader 1		/	Unkown
HY-131871	Ethyl LipotF	Inhibitor	99.25%	Unkown
HY-RS05137	Fto Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-117275S	Meclofenamic acid-d4	Inhibitor	/	Unkown
HY-117275S1	Meclofenamic acid-13C6	Inhibitor	/	Unkown
HY-132863	FTO-IN-2		/	Unkown
HY-138843	FTO-IN-1		/	Unkown
HY-139820	FTO-IN-4		/	Unkown
HY-139821	FTO-IN-5		/	Unkown
HY-156405	FTO-IN-10		/	Unkown
HY-168483	FTO-IN-13		/	Unkown
HY-172399	FTO-IN-14		/	Unkown
HY-175886	FTO ligand-1		/	Unkown
HY-179266	FTO-IN-15	Inhibitor	/	Unkown
HY-179267	FTO-IN-16		/	Unkown
HY-183325	FTO-IN-17	Inhibitor	/	Unkown
HY-N10340	Clausine E	Inhibitor	/	Unkown
HY-RS05138	Fto Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W026109	FTO-IN-12	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FTO	VGNC	VGNC:29138
Canis familiaris	FTO	VGNC	VGNC:41003
Rattus norvegicus	FTO	RGD	RGD:1305121
Felis catus	FTO	VGNC	VGNC:62384
Macaca mulatta	FTO	VGNC	VGNC:72772
Mus musculus	FTO	MGD	MGI:1347093
Others	FTO	NCBI