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Art. -Nr.: HY-175886

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FTO ligand-1

FTO ligand-1 is a FTO ligand for FTO PROTAC degrader FP54 (HY-175885). FTO ligand-1 can inhibit cell proliferation and block the FP54-induced FTO degradation. FTO ligand-1 can be used for research of cancer, such as acute myeloid leukemia (AML).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₇H₃₀Cl₂N₄O₅
Molecular Weight:561.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

FTO ligand-1 Chemical Structure

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

FTO ligand-1 shows anti-proliferative activity in NB4 cells with an EC₅₀ of 19 μM^[1].
FTO ligand-1 (0.4-10 μM, 2 h) dose-dependently blocks the FP54 (HY-175885)-induced FTO degradation in NB4 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

NB4 cells
Concentration:

0.4, 2 and 10 μM, companied with FP54 (HY-175885) (2 μM)
Incubation Time:

2 h
Result:

Dose-dependently blocked the FP54 (HY-175885)-induced FTO degradation.

Chemical Information

Molecular Weight 561.46
Formel C₂₇H₃₀Cl₂N₄O₅
SMILES

ClC1=C(NC2=CC=CC(N3CCNCC3)=C2C(OCOC(C(C)C)=O)=O)C(Cl)=CC(C4=C(C)ON=C4C)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li W, et al. FTO degrader impairs ribosome biogenesis and protein translation in acute myeloid leukemia. Sci Adv. 2025 Aug 15;11(33):eadv7648. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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