WEE2 - WEE2 oocyte meiosis inhibiting kinase Gene
Also Known as OOMD5; WEE1B
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 494551
About WEE2
Cytogenetic location: 7q34
Genomic coordinates (GRCh38): 7:141,708,353-141,731,271 (from NCBI)
This gene has 2 transcripts (splice variants), 1 gene allele, 197 orthologues, 8 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.
Summary
Predicted to enable protein tyrosine kinase activity. Predicted to be involved in several processes, including female pronucleus assembly; negative regulation of oocyte maturation; and regulation of meiosis I. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
WEE2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001105558.1 | NP_001099028.1 | wee1-like protein kinase 2 |
WEE2 Protein Structure
Pkinase
Pkinase: Protein kinase domain (214 - 482)
- 0
- 100
- 200
- 300
- 400
- 500
- 567 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
wee1-like protein kinase 2 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Oocyte Maturation Defect 5 |
|
|
| Female Infertility Due To Oocyte Meiotic Arrest |
|
|
| Infertility |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(2)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-103029 | Bosutinib isomer | Inhibitor | 99.62% | Unkown |
| HY-RS15808 | WEE2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | WEE2 | VGNC | VGNC:84758 |
| Bos taurus | WEE2 | VGNC | VGNC:36931 |
| Rattus norvegicus | WEE2 | RGD | RGD:1587197 |
| Mus musculus | WEE2 | MGD | MGI:3027899 |
| Canis familiaris | WEE2 | VGNC | VGNC:48403 |
| Felis catus | WEE2 | VGNC | VGNC:67070 |
| Others | WEE2 | NCBI |
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