Scn3a - sodium voltage-gated channel alpha subunit 3 Gene

Also Known as SCIII; Scn2a; Nav1.3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 497770

About Scn3a

Primary_assembly 3: 50,148,139-50,258,119 reverse strand.mRatBN7.2:CM026976.1

This gene has 4 transcripts (splice variants), 130 orthologues, 26 paralogues and is associated with 24 phenotypes. Biased expression in Brain (RPKM 164.9), Muscle (RPKM 25.) and 5 other tissues.

Summary

Enables Calmodulin binding activity; sodium ion binding activity; and voltage-gated Sodium Channel activity. Involved in several processes, including cellular response to antibiotic; neuronal action potential; and response to pyrethroid. Located in axon and neuronal cell body. Part of voltage-gated Sodium Channel complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 62 and focal epilepsy. Orthologous to human SCN3A (sodium voltage-gated channel alpha subunit 3). [provided by Alliance of Genome Resources, Apr 2022]

Scn3a Products (1)

mRNA Protein Name
NM_013119.2 NP_037251.2 sodium channel protein type 3 subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calmodulin binding IDA
IDA: Inferred from direct assay
16912065 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15317864 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to antibiotic IDA
IDA: Inferred from direct assay
18839021 RGD
involved in nervous system development IEP
IEP: Inferred from expression pattern
19269275 RGD
involved in response to pyrethroid IDA
IDA: Inferred from direct assay
19026681 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
16966585 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16966585 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn3a Protein Structure

Ion_trans

Ion_trans: pfam00520 (126 - 433)

Na_trans_cytopl

Na_trans_cytopl: pfam11933 (557 - 692)

Ion_trans

Ion_trans: pfam00520 (741 - 954)

Na_trans_assoc

Na_trans_assoc: pfam06512 (980 - 1182)

Ion_trans

Ion_trans: pfam00520 (1187 - 1459)

Na_channel_gate

Na_channel_gate: cd13433 (1451 - 1503)

Ion_trans

Ion_trans: pfam00520 (1507 - 1763)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1983 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 3 subunit alpha

  • rCG26412-like

  • sodium channel protein type 3 subunit alpha-like

  • sodium channel protein type III subunit alpha

  • sodium channel protein, brain III subunit alpha

  • sodium channel, voltage-gated, type 3, alpha subunit

  • sodium channel, voltage-gated, type III, alpha subunit

  • voltage-gated sodium channel subtype III

  • voltage-gated sodium channel subunit alpha Nav1.3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12533 SCN3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12534 Scn3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12535 Scn3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn3a NCBI NCBI:6328