Dut - deoxyuridine triphosphatase Gene

Rattus norvegicus

Also known as Dutp; PIP4

Gene ID: 497778 | Gene type: protein coding

About Dut

Summary

Enables several functions, including dUTP diphosphatase activity; peroxisome proliferator activated receptor binding activity; and pyrimidine deoxyribonucleotide binding activity. Involved in several processes, including liver development; pyrimidine deoxyribonucleotide metabolic process; and regulation of protein-containing complex assembly. Located in cytosol and nucleus. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Apr 2022]

Dut Products(2)

mRNA	Protein	Name
NM_001040271.2	NP_001035361.1	deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2
NM_053592.3	NP_446044.1	deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables dUTP diphosphatase activity	IDA IDA: Inferred from direct assay	1315924	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	3032103	RGD
enables peroxisome proliferator activated receptor binding	IPI IPI: Inferred from physical interaction	8910358	RGD
enables pyrimidine deoxyribonucleotide binding	IDA IDA: Inferred from direct assay	3032103	RGD
enables signaling receptor inhibitor activity	IDA IDA: Inferred from direct assay	8910358	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in dUMP biosynthetic process	IDA IDA: Inferred from direct assay	1315924	RGD
involved in dUTP catabolic process	IDA IDA: Inferred from direct assay	1315924	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	11121581	RGD
involved in regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	8910358	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	2841940	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

deoxyuridine 5'-triphosphate nucleotidohydrolase

PPAR-interacting protein 4	dUTP pyrophosphatase
dUTPase

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04071	DUT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dut	NCBI	NCBI:1854

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