Smad4 - SMAD family member 4 Gene

Also Known as Madh4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50554

Summary

Enables DNA binding activity; SMAD binding activity; and filamin binding activity. Involved in several processes, including ERK1 and ERK2 cascade; cellular response to glucose stimulus; and positive regulation of cardiac muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of protein-containing complex. Used to study pulmonary fibrosis. Biomarker of several diseases, including artery disease (multiple); gastrointestinal system Cancer (multiple); lung disease (multiple); prostatitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ Cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (Smad Family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Smad4 Products (1)

mRNA Protein Name
NM_019275.3 NP_062148.1 mothers against decapentaplegic homolog 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
16959941 RGD
enables SMAD binding IPI
IPI: Inferred from physical interaction
16959941 RGD
enables filamin binding IPI
IPI: Inferred from physical interaction
20167606 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15153551 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
16959941 RGD
Biological Process GO Annotation Evidence References Source
involved in ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
11401854 RGD
involved in adrenal gland development IEP
IEP: Inferred from expression pattern
12844345 RGD
involved in cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
26873969 RGD
involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
24941801 RGD
involved in negative regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
20097766 RGD
involved in osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
19940863 RGD
involved in ovarian follicle development IEP
IEP: Inferred from expression pattern
15698987 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
15949472 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
16959941 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 4

  • MAD (mothers against decapentaplegic Drosophila) homolog 4

  • MAD homolog 4

  • SMAD 4

  • mothers against DPP homolog 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149414 MY-673 98.60% Unkown
HY-RS13395 SMAD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P11223 CMF9 Inhibitor 98.65% Unkown
HY-179228 AN02 / Unkown
HY-RS17346 Smad4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23800 Smad4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad4 NCBI NCBI:4089