Ctss - cathepsin S Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50654

About Ctss

Primary_assembly 2: 183,086,437-183,114,483 forward strand.mRatBN7.2:CM026975.1

This gene has 3 transcripts (splice variants), 270 orthologues, 27 paralogues and is associated with 29 phenotypes. Biased expression in Spleen (RPKM 78.2), Brain (RPKM 595.9) and 9 other tissues.

Summary

Enables cysteine-type peptidase activity. Involved in bone resorption; metanephros development; and regulation of sensory perception of pain. Located in cell surface. Biomarker of intracranial aneurysm. Human ortholog(s) of this gene implicated in neuropathy. Orthologous to human CTSS (Cathepsin S). [provided by Alliance of Genome Resources, Apr 2022]

Ctss Products (1)

mRNA Protein Name
NM_017320.2 NP_059016.2 cathepsin S preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
11570845 RGD
Biological Process GO Annotation Evidence References Source
involved in bone resorption IMP
IMP: Inferred from mutant phenotype
10470376 RGD
involved in metanephros development IEP
IEP: Inferred from expression pattern
16153003 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
16436681 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctss Protein Structure

Inhibitor_I29

Inhibitor_I29: smart00848 (36 - 95)

Peptidase_C1

Peptidase_C1: pfam00112 (123 - 338)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
Protein Preferred Names Protein Names

cathepsin S

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70226 Cathepsin S, human / Unkown
HY-RS03345 Ctss Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182614 BJ-2302 Inhibitor / Unkown
HY-RS03344 CTSS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03346 Ctss Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990387 Anti-CTSS/Cathepsin S Antibody (Fsn0503h) 99.28% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctss NCBI NCBI:1520
Mus musculus Ctss NCBI NCBI:13040