TRAT1 - T cell receptor associated transmembrane adaptor 1 Gene

Homo sapiens

Also known as TRIM; TCRIM; HSPC062; pp29/30

Gene ID: 50852 | Gene type: protein coding

About TRAT1

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:108,822,786-108,855,005 (from NCBI)

This gene has 5 transcripts (splice variants) and 113 orthologues. Biased expression in lymph node (RPKM 11.9), appendix (RPKM 6.4) and 9 other tissues.

Summary

Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within negative regulation of receptor recycling; negative regulation of transport; and positive regulation of signal transduction. Located in centriolar satellite; mitotic spindle; and plasma membrane. Part of T cell receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

TRAT1 Products(2)

mRNA	Protein	Name
NM_001317747.2	NP_001304676.1	T-cell receptor-associated transmembrane adapter 1 isoform 2
NM_016388.4	NP_057472.2	T-cell receptor-associated transmembrane adapter 1 isoform 1

TRAT1 Protein Structure

SIT

0
100
186 a.a.

Protein Preferred Names

Protein Names

T-cell receptor-associated transmembrane adapter 1

T cell receptor interacting molecule

Recombinant TRAT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71379	TRAT1 Protein, Human (His)	Q6PIZ9 (N29-N186)	≥95%

Related Diseases

Diseases

Alias

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h

Lgmd2h	Limb-Girdle Muscular Dystrophy Due To Trim32 Deficiency
Muscular Dystrophy Hutterite Type	Sarcotubular Myopathy
Limb-Girdle Muscular Dystrophy Type 2h

Mulibrey Nanism

MUL	Muscle-Liver-Brain-Eye Nanism
Pericardial Constriction And Growth Failure	Perheentupa Syndrome
Mulibrey Growth Disorder	Mulibrey Nanism Syndrome
Pericardial Constriction With Growth Failure	Nanism Mulibrey

Inclusion Conjunctivitis

Chlamydial Conjunctivitis	Inclusion Blennorrhoea
Paratrachoma	Adult Inclusion Conjunctivitis
Inclusion Blenorrhea	Conjunctivitis, Inclusion
Neonatal Chlamydial Conjunctivitis	Inclusion Conjunctivitis Of The Adult
Chronic Conjunctivitis Due To Chlamydia Trachomatis	Inclusion Conjunctivitis Due To Chlamydia Trachomatis
Acute Follicular Conjunctivitis, Chlamydial	Adult Chlamydial Keratoconjunctivitis

Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14996	TRAT1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRAT1	VGNC	VGNC:79865
Rattus norvegicus	TRAT1	RGD	RGD:1563011
Canis familiaris	TRAT1	VGNC	VGNC:47789
Felis catus	TRAT1	VGNC	VGNC:102858
Mus musculus	TRAT1	MGD	MGI:1924897
Bos taurus	TRAT1	VGNC	VGNC:36295
Others	TRAT1	NCBI

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