TRAT1 - T cell receptor associated transmembrane adaptor 1 Gene

Also Known as TRIM; TCRIM; HSPC062; pp29/30

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50852

About TRAT1

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:108,822,786-108,855,005 (from NCBI)

This gene has 5 transcripts (splice variants) and 113 orthologues. Biased expression in lymph node (RPKM 11.9), appendix (RPKM 6.4) and 9 other tissues.

Summary

Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within negative regulation of receptor recycling; negative regulation of transport; and positive regulation of signal transduction. Located in centriolar satellite; mitotic spindle; and plasma membrane. Part of T cell receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

TRAT1 Products (2)

mRNA Protein Name
NM_001317747.2 NP_001304676.1 T-cell receptor-associated transmembrane adapter 1 isoform 2
NM_016388.4 NP_057472.2 T-cell receptor-associated transmembrane adapter 1 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of receptor recycling IDA
IDA: Inferred from direct assay
11390434 GOA
acts upstream of or within negative regulation of transport IDA
IDA: Inferred from direct assay
11390434 GOA
acts upstream of or within positive regulation of T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
11390434 GOA
acts upstream of or within positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
11390434 GOA
Cellular Component GO Annotation Evidence References Source
part of T cell receptor complex IDA
IDA: Inferred from direct assay
11390434 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11390434 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAT1 Protein Structure

SIT

SIT: SHP2-interacting transmembrane adaptor protein, SIT (12 - 121)

  • 0
  • 100
  • 186 a.a.
Protein Preferred Names Protein Names

T-cell receptor-associated transmembrane adapter 1

  • T cell receptor interacting molecule

TRAT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRAT1 Q6PIZ9 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TRAT1 Proteins

Cat. No. Product Name Accession Purity
HY-P71379 TRAT1 Protein, Human (His) Q6PIZ9 (N29-N186) ≥ 95%, as determined by reducing SDS-PAGE.

TRAT1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810126 TRIM Antibody (YA9470) WB, IP, FC human

Related Diseases

Diseases Alias
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h

  • Lgmd2h

  • Limb-Girdle Muscular Dystrophy Due To Trim32 Deficiency

  • Muscular Dystrophy Hutterite Type

  • Sarcotubular Myopathy

  • Limb-Girdle Muscular Dystrophy Type 2h
Mulibrey Nanism

  • MUL

  • Muscle-Liver-Brain-Eye Nanism

  • Pericardial Constriction And Growth Failure

  • Perheentupa Syndrome

  • Mulibrey Growth Disorder

  • Mulibrey Nanism Syndrome

  • Pericardial Constriction With Growth Failure

  • Nanism Mulibrey
Inclusion Conjunctivitis

  • Chlamydial Conjunctivitis

  • Inclusion Blennorrhoea

  • Paratrachoma

  • Adult Inclusion Conjunctivitis

  • Inclusion Blenorrhea

  • Conjunctivitis, Inclusion

  • Neonatal Chlamydial Conjunctivitis

  • Inclusion Conjunctivitis Of The Adult

  • Chronic Conjunctivitis Due To Chlamydia Trachomatis

  • Inclusion Conjunctivitis Due To Chlamydia Trachomatis

  • Acute Follicular Conjunctivitis, Chlamydial

  • Adult Chlamydial Keratoconjunctivitis
Autosomal Recessive Limb-Girdle Muscular Dystrophy

  • Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14996 TRAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21795 Trat1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28311 Trat1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TRAT1 VGNC VGNC:79865
Rattus norvegicus TRAT1 RGD RGD:1563011
Canis familiaris TRAT1 VGNC VGNC:47789
Felis catus TRAT1 VGNC VGNC:102858
Mus musculus TRAT1 MGD MGI:1924897
Bos taurus TRAT1 VGNC VGNC:36295
Others TRAT1 NCBI