Il27ra - interleukin 27 receptor, alpha Gene

Also Known as CRL1; Tccr; Wsx1; WSX-1; IL-27R; zcytor1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 50931

Summary

Enables interleukin-27 receptor activity. Involved in negative regulation of T cell extravasation; negative regulation of T-helper 17 type immune response; and negative regulation of cytokine production. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; and regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. Predicted to be located in cytoplasm; extracellular region; and plasma membrane. Predicted to be part of interleukin-12 receptor complex and interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in decidua; decidua basalis; embryo; and extraembryonic component. Orthologous to human IL27RA (interleukin 27 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Il27ra Products (1)

mRNA	Protein	Name
NM_016671.3	NP_057880.2	interleukin-27 receptor subunit alpha precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-27 receptor activity	IDA IDA: Inferred from direct assay	12121660	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12121660	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	11057672	MGI
involved in negative regulation of T cell extravasation	IGI IGI: Inferred from genetic interaction	22927332	MGI
involved in negative regulation of T-helper 17 type immune response	IGI IGI: Inferred from genetic interaction	22927332	MGI
involved in negative regulation of cellular extravasation	IGI IGI: Inferred from genetic interaction	22927332	MGI
involved in negative regulation of interleukin-17 production	IGI IGI: Inferred from genetic interaction	22927332	MGI
involved in negative regulation of interleukin-6 production	IGI IGI: Inferred from genetic interaction	22927332	MGI
involved in negative regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	22927332	MGI
acts upstream of or within negative regulation of type 2 immune response	IMP IMP: Inferred from mutant phenotype	11057672	MGI
acts upstream of or within positive regulation of T-helper 1 type immune response	IMP IMP: Inferred from mutant phenotype	11057672	MGI
acts upstream of or within positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	11057672	MGI
acts upstream of or within regulation of isotype switching to IgG isotypes	IMP IMP: Inferred from mutant phenotype	11057672	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interleukin-27 receptor subunit alpha	IL-27 receptor subunit alpha IL-27R subunit alpha IL-27R-alpha IL-27RA T cell cytokine receptor T cell cytokine receptor cytokine receptor family, class 1 (WSXWS), member 1 cytokine receptor family, class 1 (WSXWS), member 1 type I T-cell cytokine

Recombinant Il27ra Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76668	IL-27R alpha/TCCR Protein, Mouse (HEK293, His)	O70394 (G29-K510)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06747	IL27RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174612	Human IL27RA mRNA		/	Unkown
HY-RS20169	Il27ra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26673	Il27ra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992246	Anti-IL-27RA Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il27ra	NCBI	NCBI:9466