PHF20L1 - PHD finger protein 20 like 1 Gene

Also Known as URLC1; CGI-72; TDRD20B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51105

About PHF20L1

Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:132,775,388-132,848,807 (from NCBI)

This gene has 20 transcripts (splice variants), 176 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 4.7) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Predicted to be involved in histone acetylation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of NSL complex. [provided by Alliance of Genome Resources, Apr 2022]

PHF20L1 Products (4)

mRNA Protein Name
NM_001277196.2 NP_001264125.1 PHD finger protein 20-like protein 1 isoform 4
NM_001362971.2 NP_001349900.1 PHD finger protein 20-like protein 1 isoform 4
NM_016018.5 NP_057102.4 PHD finger protein 20-like protein 1 isoform 1
NM_198513.2 NP_940915.1 PHD finger protein 20-like protein 1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables methylation-dependent protein binding IPI
IPI: Inferred from physical interaction
24492612 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16415788 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
24492612 GOA
involved in negative regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
29358331 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHF20L1 Protein Structure

DUF3776

DUF3776: Protein of unknown function (DUF3776) (210 - 317)

DUF3776

DUF3776: Protein of unknown function (DUF3776) (423 - 516)

PHD

PHD: PHD-finger (683 - 727)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1017 a.a.
Protein Preferred Names Protein Names

PHD finger protein 20-like protein 1

  • tudor domain containing 20B

PHF20L1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PHF20L1 A8MW92 H4C16 Homo sapiens P62805
Pull Down
16415788
Intra
PHF20L1 A8MW92 H3C1 Homo sapiens P68431
Pull Down
16415788
Intra
PHF20L1 A8MW92 H3C1 Homo sapiens P68431
Protein Array
16415788
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cutaneous Adenocystic Carcinoma

  • Adenoid Cystic Eccrine Carcinoma

  • Adenoid Cystic Carcinoma Of The Skin

  • Adenoid Cystic Eccrine Carcinoma Of Skin
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10422 PHF20L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PHF20L1 VGNC VGNC:84100
Bos taurus PHF20L1 VGNC VGNC:32820
Canis familiaris PHF20L1 VGNC VGNC:44486
Mus musculus PHF20L1 MGD MGI:2444412
Felis catus PHF20L1 VGNC VGNC:64141
Rattus norvegicus PHF20L1 RGD RGD:1560141
Others PHF20L1 NCBI