NAA20 - N-alpha-acetyltransferase 20, NatB catalytic subunit Gene

Also Known as NAT3; NAT5; MRT73; NAT3P; NAT5P; dJ1002M8.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51126

About NAA20

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:20,017,290-20,033,655 (from NCBI)

This gene has 7 transcripts (splice variants), 214 orthologues, 4 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 49.8), testis (RPKM 35.7) and 25 other tissues.

Summary

NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009]

NAA20 Products (3)

mRNA Protein Name
NM_016100.5 NP_057184.1 N-alpha-acetyltransferase 20 isoform a
NM_181527.3 NP_852668.1 N-alpha-acetyltransferase 20 isoform b
NM_181528.3 NP_852669.1 N-alpha-acetyltransferase 20 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18570629 GOA
Biological Process GO Annotation Evidence References Source
involved in N-terminal peptidyl-aspartic acid acetylation IDA
IDA: Inferred from direct assay
34230638 GOA
involved in N-terminal peptidyl-glutamic acid acetylation IDA
IDA: Inferred from direct assay
34230638 GOA
involved in N-terminal peptidyl-glutamine acetylation IDA
IDA: Inferred from direct assay
34230638 GOA
involved in N-terminal protein amino acid acetylation IDA
IDA: Inferred from direct assay
34230638 GOA
Cellular Component GO Annotation Evidence References Source
part of NatB complex IPI
IPI: Inferred from physical interaction
18570629 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18570629 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25732826 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA20 Protein Structure

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (50 - 128)

  • 0
  • 100
  • 178 a.a.
Protein Preferred Names Protein Names

N-alpha-acetyltransferase 20

  • N-acetyltransferase 3 homolog

NAA20 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NAA20 P61599 NAA25 Homo sapiens Q14CX7
Anti Bait CoIP
18570629
Intra
NAA20 P61599 NAA25 Homo sapiens Q14CX7
Anti Tag CoIP
18570629
Cross: Cross-species interaction Intra: Intraspecies interaction

NAA20 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811239 NAT5 Antibody WB, IHC-P, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Recessive 73

  • MRT73

  • Autosomal Recessive Intellectual Developmental Disorder 73
Autosomal Recessive Non-Syndromic Intellectual Disability

  • Ar-Nsid

  • Ns-Arid
Microphthalmia, Syndromic 1

  • MCOPS1

  • Lenz Microphthalmia Syndrome

  • Lenz Dysplasia

  • Mcops4

  • Syndromic Microphthalmia 1

  • Lenz Microphthalmia

  • Maa

  • Microphthalmia Or Anophthalmos With Associated Anomalies

  • Syndromic Microphthalmia Type 4

  • Microphthalmia, Syndromic 4

  • Microphthalmia, Syndromic 4, Formerly

  • Mcops4, Formerly

  • Anop1, Formerly

  • Maa, Formerly

  • Lenz Type Microphthalmia

  • Syndromic Microphthalmia 4

  • Microphthalmia Lenz Type

  • Microphthalmia Syndromic 1

  • Syndromic Microphthalmia Type 1

  • Microphthalmia Syndromic 4

  • Microphthalmia With Ankyloblepharon And Intellectual Disability

  • Microphthalmia, Lenz Type

  • Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

  • Microphthalmia, Syndromic, 1

  • Anop1

  • Microphthalmia, Syndromic, Type 1
Syndromic Microphthalmia

  • Microphthalmia, Syndromic
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08988 NAA20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NAA20 VGNC VGNC:82879
Rattus norvegicus NAA20 RGD RGD:1307713
Macaca mulatta NAA20 VGNC VGNC:84533
Canis familiaris NAA20 VGNC VGNC:54751
Bos taurus NAA20 VGNC VGNC:57011
Mus musculus NAA20 MGD MGI:1915127
Others NAA20 NCBI