2. Gene
  3. SERPINA10 - serpin family A member 10 Gene

SERPINA10 - serpin family A member 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PZI; ZPI

Gene ID: 51156 | Gene type: protein coding

About SERPINA10

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,280,460-94,293,268 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 256 orthologues, 36 paralogues and is associated with 1 phenotype. Restricted expression toward liver (RPKM 44.6).

Summary

The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]

SERPINA10 Products(2)

mRNA Protein Name
NM_001100607.3 NP_001094077.1 protein Z-dependent protease inhibitor precursor
NM_016186.3 NP_057270.1 protein Z-dependent protease inhibitor precursor

SERPINA10 Protein Structure

Serpin

Serpin: Serpin (serine protease inhibitor) (79 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 444 a.a.
Protein Preferred Names Protein Names

protein Z-dependent protease inhibitor

PZ-dependent protease inhibitor

Recombinant SERPINA10 Proteins

Cat. No. Product Name Accession Purity
HY-P71292 Serpin A10 Protein, Human (HEK293, His) Q9UK55 (L22-L444) ≥95%

Related Diseases

Diseases Alias
Thrombosis

Thrombosis Of Blood Vessel
Protein Z Deficiency
Thrombophilia

Hypercoagulability State
Shwartzman Phenomenon

Shwartzman Reaction
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12697 SERPINA10 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SERPINA10 RGD RGD:621220
Mus musculus SERPINA10 MGD MGI:2667725
Macaca mulatta SERPINA10 VGNC VGNC:77242
Bos taurus SERPINA10 VGNC VGNC:34465
Others SERPINA10 NCBI