PDE3A - phosphodiesterase 3A Gene

Also Known as HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5139

About PDE3A

Cytogenetic location: 12p12.2 Genomic coordinates (GRCh38): 12:20,368,537-20,688,583 (from NCBI)

This gene has 3 transcripts (splice variants), 258 orthologues, 20 paralogues and is associated with 2 phenotypes. Broad expression in heart (RPKM 15.7), placenta (RPKM 7.2) and 17 other tissues.

Summary

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE Enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

PDE3A Products (5)

mRNA	Protein	Name
NM_001378407.1	NP_001365336.1	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 3
NM_001244683.2	NP_001231612.1	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 2
NM_000921.5	NP_000912.3	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 1
NM_001378408.1	NP_001365337.1	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 4
NM_001378409.1	NP_001365338.1	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	IDA IDA: Inferred from direct assay	8155697	GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	8155697	GOA
enables 3',5'-cyclic-GMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	8155697	GOA
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IDA IDA: Inferred from direct assay	27975297	GOA
enables estrogen binding	IDA IDA: Inferred from direct assay	31420216	GOA
enables nuclear estrogen receptor activity	IDA IDA: Inferred from direct assay	31420216	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19332778	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	31420216	GOA
involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	31420216	GOA
involved in cAMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	17704206	GOA
involved in cGMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	17704206	GOA
involved in cellular response to cGMP	IDA IDA: Inferred from direct assay	17704206	GOA
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	17704206	GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19252089	GOA
involved in negative regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	17704206	GOA
involved in positive regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	17704206	GOA
involved in regulation of ribonuclease activity	IDA IDA: Inferred from direct assay	34272366	GOA
involved in regulation of ribonuclease activity	IMP IMP: Inferred from mutant phenotype	35104454	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	35104454	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE3A Protein Structure

PDEase_I

0
200
400
600
800
1000
1141 a.a.

Protein Preferred Names	Protein Names
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A	cAMP phosphodiesterase, myocardial cGMP-inhibited cGMP-inhibited 3',5'-cyclic phosphodiesterase A cGMP-inhibited cAMP phosphodiesterase cyclic GMP-inhibited phosphodiesterase A phosphodiesterase 3A, cGMP-inhibited

PDE3A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDE3A	Q14432	ARFGEF1	Homo sapiens	Q9Y6D6	Anti Bait CoIP	19332778
Intra	PDE3A	Q14432	ARFGEF2	Homo sapiens	Q9Y6D5	Anti Bait CoIP	19332778

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDE3A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75961	PDE3A Protein, Human (sf9, His-GST)	Q14432 (K669-Q1141)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Brachydactyly
Osseous Heteroplasia, Progressive	Progressive Osseous Heteroplasia POH Osteoma Cutis Familial Ectopic Ossification Ectopic Ossification Familial Type Ectopic Ossification Heterotopic Ossification Ectopic Ossification, Familial Cutaneous Ossification Myositis Ossificans Progressiva Osteodermia Osteosis Cutis Ossification Heterotopic Heteroplasia, Osseous, Progressive Fibrodysplasia Ossificans Progressiva
Impotence	Erectile Dysfunction Sexual Impotence Erectile Dysfunction Adverse Event
Acrodysostosis	Acrodysplasia Arkless-Graham Syndrome Maroteaux-Malamut Syndrome Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Chromosome 2q37 Deletion Syndrome	Albright Hereditary Osteodystrophy-Like Syndrome 2q37 Microdeletion Syndrome Brachydactyly-Intellectual Disability Syndrome Deletion 2q37 2q37 Deletion Syndrome Brachydactyly-Mental Retardation Syndrome Bdmr Albright Hereditary Osteodystrophy Type 3 Del(2)(Q37) Monosomy 2q37qter Albright'S Hereditary Osteodystrophy-Like Syndrome Monosomy 2q37 Chromosome Deletion Syndrome 2q37
Tooth Ankylosis	Ankylosis Of Teeth Ankylosis Of Tooth
Severe Congenital Neutropenia 8	Autosomal Dominant Severe Congenital Neutropenia 8 With Or Without Pancreatic Dysfunction And/Or Neurological Abnormalities Scn8 Sdsl Shwachman-Diamond Syndrome-Like
Pseudopseudohypoparathyroidism	PPHP Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance Normocalcemic Pseudohypoparathyroidism Aho-Pphp Syndrome Albright Hereditary Osteodystrophy-Pphp Syndrome Pseudohypoparathyroidism
Hypertension And Brachydactyly Syndrome	Brachydactyly With Hypertension Bilginturan Syndrome HTNB Brachydactyly-Arterial Hypertension Syndrome Brachydactyly, Type E, With Short Stature And Hypertension Bilginturan Brachydactyly Brachydactyly Type E With Short Stature And Hypertension Type E Brachydactyly With Short Stature And Hypertension Brachydactyly Type E, With Short Stature And Hypertension Hypertension With Brachydactyly
Congestive Heart Failure	Congestive Heart Disease Heart Failure Cardiac Failure Congestive Chf Weak Heart Heart Failure Congestive Ccf - [Congestive Cardiac Failure] Chf - [Congestive Heart Failure] Congestive Cardiac Diseases Congested Heart Failure Congestive Cardiac Failure Cardiac Anasarca Cardiac Oedema Cardiac Stasis Cardiovascular Oedema Cardiac Hydrops Congestive Failure Heart Congestion Heart Fluid Oedematous Heart
Pseudohypoparathyroidism, Type Ia	Albright'S Hereditary Osteodystrophy Albright Hereditary Osteodystrophy Pseudohypoparathyroidism Type 1a PHP1A Albright Hereditary Osteodystrophy With Multiple Hormone Resistance Pseudohypoparathyroidism Ia AHO Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy Pseudo-Pseudohypoparathyroidism Pseudohypoparathyroidism Type I A Php Ia Pseudopseudohypoparathyroidism Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance Pphp Pseudopseudo-Hypoparathyroidism Aho-Php Syndrome Ia Albright Hereditary Osteodystrophy-Php Syndrome Ia Pseudohypoparathyroidism 1a Pseudohypoparathyroidism
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Hypothyroidism, Congenital, Nongoitrous, 1	Tsh Resistance CHNG1 Hypothyroidism Due To Tsh Receptor Mutations Thyrotropin Resistance Rtsh Hypothyroidism Due To Unresponsiveness To Thyrotropin Congenital Nongoitrous Hypothyroidism 1 Thyroid-Stimulating Hormone Thyroid-Stimulating Hormone, Resistance To Hypothyroidism, Nonautoimmune Hypothyroidism, Congenital, Due To Tsh Resistance Hypothyroidism, Congenital, Non-Goitrous, 1 Congenital Hypothyroidism Due To Tsh Resistance Non-Autoimmune Hypothyroidism Thyroid-Stimulating Hormone Resistance Hypothyroidism, Congenital, Nongoitrous, Type 1 Hypothyroidism, Congenital, Nongoitrous, 3 Thyroid Hormone Resistance Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112831	Osoresnontrine	Inhibitor	99.94%	Phase 2
HY-A0165	Tofisopam	Inhibitor	99.94%	Phase 2
HY-U00186	K134	Inhibitor	99.76%	Phase 2
HY-111167	AN-2898	Inhibitor	/	Phase 2
HY-145924	BAY 2666605	Inhibitor	99.74%	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101312	Cilostamide	Inhibitor	99.13%	Unkown
HY-136350	BRD9500	Modulator	98.41%	Unkown
HY-W028690	DNMDP	Inhibitor	99.46%	Unkown
HY-162730	OPB-171775	Inhibitor	99.80%	Unkown
HY-100530C	Sp-cAMPS sodium salt		99.45%	Unkown
HY-122751	(R)-DNMDP	Inhibitor	99.59%	Unkown
HY-100530B	Sp-cAMPS		/	Unkown
HY-136350B	(S)-BRD9500	Control	99.67%	Unkown
HY-N10149	Nauclefine		99.65%	Unkown
HY-110005	Sp-cAMPS triethylamine		/	Unkown
HY-112631	OPC 33540	Inhibitor	/	Unkown
HY-120945	PDE10A-IN-1	Inhibitor	/	Unkown
HY-153802	Antitumor agent-100	Inducer	/	Unkown
HY-153802A	Antitumor agent-100 hydrochloride	Inducer	/	Unkown
HY-174383	PDE3/4-IN-2	Inhibitor	99.75%	Unkown
HY-176524S	PDE3/4-IN-3	Inhibitor	/	Unkown
HY-179503	PDE/TRPA1/CHIT1-IN-1	Inhibitor	/	Unkown
HY-181088	PDE3/4-IN-4	Inhibitor	/	Unkown
HY-181762	Multitarget AD-IN-6	Inhibitor	/	Unkown
HY-RS10216	PDE3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10217	Pde3a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10218	Pde3a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-162730R	OPB-171775 (Standard)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PDE3A	VGNC	VGNC:54467
Macaca mulatta	PDE3A	VGNC	VGNC:75913
Canis familiaris	PDE3A	VGNC	VGNC:44352
Felis catus	PDE3A	VGNC	VGNC:68756
Mus musculus	PDE3A	MGD	MGI:1860764
Rattus norvegicus	PDE3A	RGD	RGD:61942
Others	PDE3A	NCBI