ACKR4 - atypical chemokine receptor 4 Gene

Also Known as PPR1; CCBP2; CCR10; CCR11; CCRL1; VSHK1; CCR-11; CKR-11; CCX CKR; CCX-CKR; CC-CKR-11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51554

About ACKR4

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:132,597,270-132,602,644 (from NCBI)

This gene has 2 transcripts (splice variants), 256 orthologues and 23 paralogues. Broad expression in duodenum (RPKM 8.4), small intestine (RPKM 7.1) and 16 other tissues.

Summary

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]

ACKR4 Products (2)

mRNA Protein Name
NM_016557.4 NP_057641.1 atypical chemokine receptor 4
NM_178445.2 NP_848540.1 atypical chemokine receptor 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables chemokine receptor activity IDA
IDA: Inferred from direct assay
23341447 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23341447 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACKR4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (58 - 303)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

atypical chemokine receptor 4

  • C-C CKR-11

Related Diseases

Diseases Alias
Sezary'S Disease

  • Sezary Syndrome

  • Sézary Syndrome

  • Sezary'S Lymphoma

  • Sezary Disease

  • Sezary Erythroderma

  • Sezary Lymphoma
Immune Deficiency Disease

  • Immunodeficiency

  • Primary Immunodeficiency

  • Primary Immunodeficiency Disease

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00165 ACKR4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22371 Ackr4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28894 Ackr4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991785 Anti-Mouse ACKR4 Antibody (A4Mab-3) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ACKR4 VGNC VGNC:69418
Mus musculus ACKR4 MGD MGI:2181676
Bos taurus ACKR4 VGNC VGNC:25542
Rattus norvegicus ACKR4 RGD RGD:1596453
Felis catus ACKR4 VGNC VGNC:59512
Canis familiaris ACKR4 VGNC VGNC:37510
Others ACKR4 NCBI