Setd3 - SET domain containing 3 Gene

Also Known as D12Ertd771e; 2610102I01Rik; 2610305M23Rik; 6030490B17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 52690

Summary

Enables N-methyltransferase activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in actin modification; peptidyl-histidine methylation; and regulation of uterine smooth muscle contraction. Acts upstream of or within positive regulation of muscle cell differentiation and positive regulation of transcription by RNA polymerase II. Located in chromatin. Orthologous to human SETD3 (SET domain containing 3, actin histidine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Setd3 Products (6)

mRNA Protein Name
NM_001364266.1 NP_001351195.1 actin-histidine N-methyltransferase isoform 1
NM_001364267.1 NP_001351196.1 actin-histidine N-methyltransferase isoform 3
NM_001364268.1 NP_001351197.1 actin-histidine N-methyltransferase isoform 4
NM_001364269.1 NP_001351198.1 actin-histidine N-methyltransferase isoform 5
NM_001364270.1 NP_001351199.1 actin-histidine N-methyltransferase isoform 6
NM_028262.3 NP_082538.2 actin-histidine N-methyltransferase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
21832073 MGI
enables histone H3K36 methyltransferase activity IDA
IDA: Inferred from direct assay
21832073 MGI
enables histone H3K4 methyltransferase activity IDA
IDA: Inferred from direct assay
21832073 MGI
enables protein-L-histidine N-tele-methyltransferase activity IMP
IMP: Inferred from mutant phenotype
30626964 MGI
Biological Process GO Annotation Evidence References Source
involved in actin modification IMP
IMP: Inferred from mutant phenotype
30626964 MGI
involved in peptidyl-histidine methylation IMP
IMP: Inferred from mutant phenotype
30626964 MGI
acts upstream of or within positive regulation of muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
21832073 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21832073 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
21832073 MGI
involved in regulation of uterine smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
30626964 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
21832073 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin-histidine N-methyltransferase

  • SET domain-containing protein 3

  • endothelial differentiation inhibitory protein D10

  • histone-lysine N-methyltransferase setd3

  • protein-L-histidine N-tele-methyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12743 SETD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19236 Setd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25725 Setd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Setd3 NCBI NCBI:84193