SETD3 - SET domain containing 3, actin histidine methyltransferase Gene

Also Known as hSETD3; C14orf154

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84193

About SETD3

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:99,397,748-99,486,458 (from NCBI)

This gene has 9 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 33.6), kidney (RPKM 26.5) and 25 other tissues.

Summary

Enables protein-L-histidine N-tele-methyltransferase activity. Involved in actin modification and peptidyl-histidine methylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SETD3 Products (2)

mRNA Protein Name
NM_032233.3 NP_115609.2 actin-histidine N-methyltransferase isoform a
NM_199123.2 NP_954574.1 actin-histidine N-methyltransferase isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
26030842 GOA
enables protein-L-histidine N-tele-methyltransferase activity IDA
IDA: Inferred from direct assay
30526847 GOA
NOT enables protein-lysine N-methyltransferase activity IDA
IDA: Inferred from direct assay
30785395 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in actin modification IDA
IDA: Inferred from direct assay
30526847 GOA
involved in peptidyl-histidine methylation IDA
IDA: Inferred from direct assay
30526847 GOA
NOT involved in peptidyl-lysine trimethylation IDA
IDA: Inferred from direct assay
30785395 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
30626964 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SETD3 Protein Structure

SET

SET: SET domain (105 - 314)

Rubis-subs-bind

Rubis-subs-bind: Rubisco LSMT substrate-binding (343 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 594 a.a.
Protein Preferred Names Protein Names

actin-histidine N-methyltransferase

  • SET domain-containing protein 3

Related Diseases

Diseases Alias
Acute Flaccid Myelitis
Sotos Syndrome 3

  • Sotos3

  • Sotos Syndrome, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12743 SETD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19236 Setd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25725 Setd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SETD3 RGD RGD:1309550
Bos taurus SETD3 VGNC VGNC:34494
Canis familiaris SETD3 VGNC VGNC:46055
Mus musculus SETD3 MGD MGI:1289184
Felis catus SETD3 VGNC VGNC:65042
Macaca mulatta SETD3 VGNC VGNC:77285
Others SETD3 NCBI