Nr4a2 - nuclear receptor subfamily 4, group A, member 2 Gene

Also Known as RNR1; Nurr1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54278

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; negative regulation of neuron apoptotic process; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within response to inorganic substance and response to Insecticide. Located in chromatin; cytoplasm; and nucleus. Biomarker of Parkinsonism and epilepsy. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr4a2 Products (1)

mRNA Protein Name
NM_019328.3 NP_062201.2 nuclear receptor subfamily 4 group A member 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8737662 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8737662 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8737662 RGD
Biological Process GO Annotation Evidence References Source
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
21056632 RGD
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
17142303 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
22294685 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8737662 RGD
acts upstream of or within response to insecticide IDA
IDA: Inferred from direct assay
8737662 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
22714110 RGD
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
28743636 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor subfamily 4 group A member 2

  • NUR-related factor 1

  • RNR-1

  • SL-322

  • nuclear orphan receptor HZF-3

  • nuclear receptor subfamily 4 group A member 2 variant NURR1a

  • nuclear receptor subfamily 4 group A member 2 variant NURR1b

  • nuclear receptor subfamily 4 group A member 2 variant NURR1c

  • n

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179528 DIM-3,5-Cl2 99.18% Unkown
HY-174340 Nurr1 agonist 13 Agonist / Unkown
HY-RS09551 NR4A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17344 Nr4a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23798 Nr4a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr4a2 NCBI NCBI:4929