Eif2ak2 - eukaryotic translation initiation factor 2-alpha kinase 2 Gene

Also Known as Pkr; Prkr

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54287

Summary

Predicted to enable double-stranded RNA binding activity; eukaryotic translation initiation factor 2alpha kinase activity; and identical protein binding activity. Involved in several processes, including response to exogenous dsRNA; response to lipopolysaccharide; and response to vitamin E. Located in nucleus. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak2 Products (1)

mRNA Protein Name
NM_019335.2 NP_062208.2 interferon-induced, double-stranded RNA-activated protein kinase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17953670 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18535002 RGD
involved in response to exogenous dsRNA IEP
IEP: Inferred from expression pattern
15920723 RGD
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
15630703 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
15781241 RGD
involved in response to toxic substance IMP
IMP: Inferred from mutant phenotype
18535002 RGD
involved in response to vitamin E IPI
IPI: Inferred from physical interaction
17953670 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon-induced, double-stranded RNA-activated protein kinase

  • Protein kinase, interferon-inducible double stranded RNA dependent

  • eIF-2A protein kinase 2

  • interferon-inducible RNA-dependent protein kinase

  • protein kinase R

  • protein kinase RNA-activated

  • tyrosine-protein kinase EIF2AK2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04243 EIF2AK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174720 Human EIF2AK2 mRNA / Unkown
HY-RS18207 Eif2ak2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24684 Eif2ak2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif2ak2 NCBI NCBI:5610