EIF2AK2 - eukaryotic translation initiation factor 2 alpha kinase 2 Gene

Also Known as PKR; PRKR; DYT33; LEUDEN; EIF2AK1; PPP1R83

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5610

About EIF2AK2

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,099,210-37,156,980 (from NCBI)

This gene has 14 transcripts (splice variants), 153 orthologues, 8 paralogues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 8.7), brain (RPKM 6.4) and 25 other tissues.

Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021]

EIF2AK2 Products (3)

mRNA	Protein	Name
NM_001135651.3	NP_001129123.1	interferon-induced, double-stranded RNA-activated protein kinase isoform a
NM_001135652.2	NP_001129124.1	interferon-induced, double-stranded RNA-activated protein kinase isoform b
NM_002759.4	NP_002750.1	interferon-induced, double-stranded RNA-activated protein kinase isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21266579	GOA
enables eukaryotic translation initiation factor 2alpha kinase activity	IMP IMP: Inferred from mutant phenotype	25329545	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16373505	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	21123651	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8576172	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	12882984	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	21123651	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	22948139	GOA
involved in cellular response to amino acid starvation	IMP IMP: Inferred from mutant phenotype	25329545	GOA
involved in defense response to virus	IEP IEP: Inferred from expression pattern	32634389	GOA
involved in negative regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	16216244	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	12882984	GOA
involved in negative regulation of translation	IMP IMP: Inferred from mutant phenotype	12610133	GOA
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	19189853	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	15229216	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	15121867	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	22801494	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	16216244	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	19189853	GOA
involved in response to interferon-alpha	IDA IDA: Inferred from direct assay	19840259	GOA
involved in response to virus	IMP IMP: Inferred from mutant phenotype	19189853	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	21123651	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15121867	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15121867	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF2AK2 Protein Structure

dsrm

Pkinase

0
100
200
300
400
500
551 a.a.

Protein Preferred Names	Protein Names
interferon-induced, double-stranded RNA-activated protein kinase	P1/eIF-2A protein kinase

EIF2AK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EIF2AK2	P19525	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	21903422
Intra	EIF2AK2	P19525	MOV10	Homo sapiens	Q9HCE1	Anti Tag CoIP	21903422
Intra	EIF2AK2	P19525	MOV10	Homo sapiens	Q9HCE1	Pull Down	32707033
Intra	EIF2AK2	P19525	EIF2S1	Homo sapiens	P05198	Competition Binding	9431994
Intra	EIF2AK2	P19525	EIF2S1	Homo sapiens	P05198	Anti Bait CoIP	9431994
Intra	EIF2AK2	P19525	EIF2S1	Homo sapiens	P05198	Protein Kinase Assay	18971339
Intra	EIF2AK2	P19525	EIF2S1	Homo sapiens	P05198	Protein Kinase Assay	9431994
Intra	EIF2AK2	P19525	ADARB1	Homo sapiens	P78563-4	Validated Y2H	32296183
Intra	EIF2AK2	P19525	DHX30	Homo sapiens	Q7L2E3	Pull Down	32707033
Intra	EIF2AK2	P19525	DHX30	Homo sapiens	Q7L2E3	TAP	23455922
Intra	EIF2AK2	P19525	DHX30	Homo sapiens	Q7L2E3	Anti Tag CoIP	21903422
Intra	EIF2AK2	P19525	PRKRA	Homo sapiens	O75569-1	NMR	16785445
Intra	EIF2AK2	P19525	PRKRA	Homo sapiens	O75569-1	Pull Down	16785445
Intra	EIF2AK2	P19525	ZNF346	Homo sapiens	Q9UL40	Pull Down	32707033
Intra	EIF2AK2	P19525	ZNF346	Homo sapiens	Q9UL40	Anti Tag CoIP	21903422
Intra	EIF2AK2	P19525	ZNF346	Homo sapiens	Q9UL40	Anti Tag CoIP	35271311
Intra	EIF2AK2	P19525	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	34035218
Intra	EIF2AK2	P19525	DHX9	Homo sapiens	Q08211	Anti Tag CoIP	35271311
Intra	EIF2AK2	P19525	DHX9	Homo sapiens	Q08211	Anti Bait CoIP	21903422
Intra	EIF2AK2	P19525	DHX9	Homo sapiens	Q08211	Anti Tag CoIP	21903422
Intra	EIF2AK2	P19525	EIF6	Homo sapiens	P56537	Anti Tag CoIP	21903422
Intra	EIF2AK2	P19525	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	21903422
Intra	EIF2AK2	P19525	CDK1	Homo sapiens	P06493	Protein Kinase Assay	20395957
Intra	EIF2AK2	P19525	NLRP3	Homo sapiens	Q96P20	Anti Bait CoIP	22801494
Intra	EIF2AK2	P19525	NLRP3	Homo sapiens	Q96P20	Anti Tag CoIP	22801494
Intra	EIF2AK2	P19525	PRKRA	Homo sapiens	O75569	TAP	23455922
Intra	EIF2AK2	P19525	PRKRA	Homo sapiens	O75569	Pull Down	32707033
Intra	EIF2AK2	P19525	PRKRA	Homo sapiens	O75569	Anti Tag CoIP	21903422
Intra	EIF2AK2	P19525	STAU2	Homo sapiens	Q9NUL3	Pull Down	32707033
Intra	EIF2AK2	P19525	STAU2	Homo sapiens	Q9NUL3	Anti Tag CoIP	21903422
Intra	EIF2AK2	P19525	FTSJ3	Homo sapiens	Q8IY81	Anti Tag CoIP	21903422
Intra	EIF2AK2	P19525	FTSJ3	Homo sapiens	Q8IY81	Pull Down	32707033
Intra	EIF2AK2	P19525	TOLLIP	Homo sapiens	Q9H0E2	Anti Tag CoIP	21903422
Intra	EIF2AK2	P19525	NPM1	Homo sapiens	P06748	Anti Bait CoIP	16957780
Intra	EIF2AK2	P19525	NPM1	Homo sapiens	P06748	Imaging	16957780
Cross	EIF2AK2	P19525	vIRF-2	Human herpesvirus 8	Q2HR71	Pull Down	11160738
Intra	EIF2AK2	P19525	TARBP2	Homo sapiens	Q15633	Anti Tag CoIP	21903422
Cross	EIF2AK2	P19525	US11	Human herpesvirus 1	P04487	Protein Kinase Assay	11836380
Cross	EIF2AK2	P19525	US11	Human herpesvirus 1	P04487	Anti Bait CoIP	11836380
Cross	EIF2AK2	P19525	DNAJC3	Bos taurus	Q27968	Pull Down	8576172
Cross	EIF2AK2	P19525	P27958-PRO_0000037570	Hepatitis C virus	P27958-PRO_0000037570	Anti Tag CoIP	12610133
Cross	EIF2AK2	P19525	P27958-PRO_0000037570	Hepatitis C virus	P27958-PRO_0000037570	IF	10390359
Cross	EIF2AK2	P19525	P27958-PRO_0000037570	Hepatitis C virus	P27958-PRO_0000037570	Pull Down	10390359
Cross	EIF2AK2	P19525	OPG041	Vaccinia virus	P20639	SPR	18971339
Cross	EIF2AK2	P19525	OPG041	Vaccinia virus	P20639	Competition Binding	9431994
Cross	EIF2AK2	P19525	P27958-PRO_0000037576	Hepatitis C virus	P27958-PRO_0000037576	Protein Kinase Assay	9143277
Cross	EIF2AK2	P19525	P27958-PRO_0000037576	Hepatitis C virus	P27958-PRO_0000037576	Y2H	9143277
Cross	EIF2AK2	P19525	P27958-PRO_0000037576	Hepatitis C virus	P27958-PRO_0000037576	Pull Down	9143277

Cross: Cross-species interaction Intra: Intraspecies interaction

EIF2AK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80283	PKR Antibody (YA124)	WB, ICC/IF, IHC-P, IP	Human
HY-P81299	Phospho-PKR (Thr451) Antibody (YA1025)	WB	Human
HY-P81299A	Phospho-PKR (Thr446) Antibody (YA1026)	WB, IHC-P, IP, ChIP	Human
HY-P81299AA	Phospho-PKR (Thr451) Antibody (YA1025) (PBS only)	WB	Human
HY-P86157	PKR Antibody (YA5849)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Dystonia 33	DYT33
Leukoencephalopathy, Developmental Delay, And Episodic Neurologic Regression Syndrome	LEUDEN Leuden Syndrome
Early-Onset Generalized Limb-Onset Dystonia	Dystonia Musculorum Deformans Eotd Early-Onset Generalized Torsion Dystonia Early-Onset Isolated Dystonia Early-Onset Primary Dystonia Early-Onset Torsion Dystonia Idiopathic Torsion Dystonia Oppenheim Dystonia Dystonia 1, Torsion, Autosomal Dominant Early Onset Torsion Dystonia Dystonia 3, Torsion, X-Linked
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Vaccinia
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Rift Valley Fever	Rfv - [Rift Valley Fever]
Chronic Fatigue Syndrome	Myalgic Encephalomyelitis Postviral Fatigue Syndrome Cfs Myalgic Encephalitis Encephalomyelitis, Myalgic Chronic Fatigue Fatigue Syndrome, Chronic Benign Myalgic Encephalomyelitis Akureyri Akureyri Disease Cfs - [Chronic Fatigue Syndrome] Epidemic Neuromyasthenia Myalgic Encephalomyelitis Syndrome Me - [Myalgic Encephalomyelitis] Pvfs - [Postviral Fatigue Syndrome] Neuromyasthenia Iceland Disease Icelandic Disease
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Hepatitis D	Delta Hepatitis Hepatitis Delta Hdv Hepatitis D Virus Hepatitis D Infection
Mumps	Parotitis Due To Mumps Virus Mumps Nos Epidemic Parotitis Infectious Parotitis
Creutzfeldt-Jakob Disease	Variant Creutzfeldt-Jakob Disease CJD Bovine Spongiform Encephalopathy Vcjd Inherited Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Familial Creutzfeldt Jakob Disease Creutzfeldt-Jacob Disease Creutzfeldt Jacob Disease Sporadic Creutzfeldt-Jakob Disease Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Disease, Variant, Resistance To Creutzfeldt-Jakob Disease, Variant Creutzfeldt Jacob Syndrome Jakob-Creutzfeldt Disease Subacute Spongiform Encephalopathy Transmissible Virus Dementia New Variant Of Cjd Nv-Cjd Variant Cjd Variant Creutzfeldt-Jacob Disease Sporadic Cjd Inherited Cjd Acquired Creutzfeldt-Jakob Disease Variant Mcj Encephalopathy Bovine Spongiform Familial Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome New Variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Sporadic Acquired Cjd Scjd - [Sporadic Creutzfeldt-Jakob Disease] Idiopathic Creutzfeldt-Jakob Disease Creutzfeld-Jakob Disease Nos Vcjd - [Variant Creutzfeldt-Jakob Disease]
Stomatitis
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Newcastle Disease	Newcastle'S Disease Pseudo-Fowlpest
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Fanconi Anemia, Complementation Group C	Fanconi Anemia Complementation Group C FANCC Facc Fac Fa3 Fanconi Pancytopenia Type 3 Fanconi Pancytopenia, Type 3 Faces Syndrome Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies Friedman-Goodman Syndrome Abnormality Of The Face
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Leukoencephalopathy With Vanishing White Matter	Cree Leukoencephalopathy Vanishing White Matter Disease Ovarioleukodystrophy Vanishing White Matter Leukodystrophy Childhood Ataxia With Central Nervous System Hypomyelinization Cach Cach Syndrome Myelinosis Centralis Diffusa VWM Cle Childhood Ataxia With Central Nervous System Hypomyelination Childhood Ataxia With Diffuse Central Nervous System Hypomyelination Cach/Vwm Cach/Vwm Syndrome Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter Cree Leukoencehalopathy Late Infantile Cach Syndrome Juvenile Or Adult Cach Syndrome Congenital Or Early Infantile Cach Syndrome Leukodystrophy With Vanishing White Matter
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04243	EIF2AK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174720	Human EIF2AK2 mRNA		/	Unkown
HY-RS18207	Eif2ak2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24684	Eif2ak2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EIF2AK2	VGNC	VGNC:69072
Mus musculus	EIF2AK2	MGD	MGI:1353449
Rattus norvegicus	EIF2AK2	RGD	RGD:3402
Macaca mulatta	EIF2AK2	VGNC	VGNC:106152
Canis familiaris	EIF2AK2	VGNC	VGNC:40257
Bos taurus	EIF2AK2	VGNC	VGNC:28381
Others	EIF2AK2	NCBI