Cldn8 - claudin 8 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54420

Summary

This intronless gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a paracellular cation barrier. [provided by RefSeq, Aug 2010]

Cldn8 Products (1)

mRNA Protein Name
NM_018778.3 NP_061248.1 claudin-8

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10601346 MGI
Cellular Component GO Annotation Evidence References Source
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
9892664 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16651389 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
9892664 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02776 CLDN8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22445 Cldn8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28968 Cldn8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990217 Anti-Mouse IL-23 p19 Antibody (G23-8) Inhibitor 99.14% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn8 NCBI NCBI:9073