2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-23 p19 Antibody (G23-8)

Anti-Mouse IL-23 p19 Antibody (G23-8) 

製品番号: HY-P990217 純度: 98.72%
COA Technical Support

Anti-Mouse IL-23 p19 Antibody (G23-8) is a rat-derived anti-mouse IL-23 p19 IgG1 monoclonal antibody. Anti-Mouse IL-23 p19 Antibody (G23-8) alleviates inflammation by restoring CLDN8 expression. Anti-Mouse IL-23 p19 Antibody (G23-8) can be used for research on inflammation conditions such as colitis and asthma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Anti-Mouse IL-23 p19 Antibody (G23-8)

Anti-Mouse IL-23 p19 Antibody (G23-8) 構造式

容量 価格（税別） 在庫状況 数量
>無料サンプル (100 μg)   今すぐ申し込む  
1 mg $260 在庫あり
5 mg $620 在庫あり
10 mg $990 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Anti-Mouse IL-23 p19 Antibody (G23-8) Featured Recommendations:

Anti-Mouse IL-23 p19 Antibody (G23-8) 関連抗体

Top Publications Citing Use of Products

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Anti-Mouse IL-23 p19 Antibody (G23-8) is a rat-derived anti-mouse IL-23 p19 IgG1 monoclonal antibody. Anti-Mouse IL-23 p19 Antibody (G23-8) alleviates inflammation by restoring CLDN8 expression. Anti-Mouse IL-23 p19 Antibody (G23-8) can be used for research on inflammation conditions such as colitis and asthma[1][2].

Isotype

Rat IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target[1][2]

IL-23

 

体外実験

Anti-Mouse IL-23 p19 Antibody (G23-8) (6 μg/mL, 72 h) reverses the significant downregulation of CLDN8 expression by IL23 in NCM460 and Caco-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-23 p19 Antibody (G23-8) 関連抗体

RT-PCR[1]

Cell Line: NCM460 and Caco-2 cells
Concentration: 6 μg/mL
Incubation Time: 72 h
Result: Reversed the significant downregulation of the CLDN8 mRNA level by IL23.

Western Blot Analysis[1]

Cell Line: NCM460 and Caco-2 cells
Concentration: 6 μg/mL
Incubation Time: 72 h
Result: Reversed the significant downregulation of the CLDN8 protein level by IL23.
体内実験

Anti-Mouse IL-23 p19 Antibody (G23-8) (0.5 mg/kg, i.p., once daily, for 3 days) reduces intestinal inflammation and increase intestinal permeability in male BALB/c mice induced with Trinitrobenzene sulfonic acid (TNBS)[1].
Anti-Mouse IL-23 p19 Antibody (G23-8) (400 μg/mouse, i.p., 1 h before every challenge period, on day 14, 15, 21, and 22) inhibits Th17 activation and neutrophilic inflammation in male C57BL/6 mice induced with Ovalbumin (OVA) or house dust mite (HDM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice (6-8 weeks) induced with Trinitrobenzene sulfonic acid (TNBS)[1]
Dosage: 0.5 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily, for 3 days
Result: Significantly alleviated intestinal inflammation.
Restored the expression of CLDN8.
Improved weight and histological score.
Increased intestinal permeability and alleviated myeloperoxidase (MPO) activity.
Animal Model: Male C57BL/6 mice induced with OVA or HDM[2]
Dosage: 400 μg/mouse
Administration: Intraperitoneal injection (i.p.), 1 h before every challenge period on day 14, 15, 21, and 22
Result: Inhibited Th17 activation and neutrophilic inflammation.
Gene ID

83430  [NCBI] & 16160  [NCBI]

Accession
Application

in vivo IL-23p19 neutralization; Western blot
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-23 p19 Antibody (G23-8)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション

純度: 98.72%

COA (232 KB) SDS-PAGE (64 KB) SEC-HPLC (161 KB)

Inhibitory Antibodies User Guide (603 KB)
参考文献
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-Mouse IL-23 p19 Antibody (G23-8) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-23 p19 Antibody (G23-8)Interleukin RelatedILIL-23p19colitisasthmaInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Anti-Mouse IL-23 p19 Antibody (G23-8)
製品番号:
HY-P990217
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.