Il12b - interleukin 12b Gene

Also Known as p40; Il-12b; Il12p40; Il-12p40

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16160

About Il12b

Chromosome 11: 44,290,890-44,304,860 forward strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 268 orthologues and is associated with 19 phenotypes. Biased expression in thymus adult (RPKM 1.), spleen adult (RPKM .3) and 4 other tissues.

Summary

This gene encodes the beta subunit p40 of the Interleukin 12 (IL-12) family of cytokines. Members of the IL-12 family form heterodimers consisting of heavy and light subunits linked by disulfide bonds. The product of this gene, p40, is a subunit of interleukins IL-12 and IL-23. [provided by RefSeq, Dec 2014]

Il12b Products (1)

mRNA Protein Name
NM_001303244.1 NP_001290173.1 interleukin-12 subunit beta precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to cytokine activity IDA
IDA: Inferred from direct assay
11057672 MGI
contributes to cytokine receptor binding IPI
IPI: Inferred from physical interaction
11114383 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
12871593 MGI
enables interleukin-12 alpha subunit binding IPI
IPI: Inferred from physical interaction
15220916 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11114383 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
11057672 MGI
acts upstream of or within T-helper 1 cell cytokine production IGI
IGI: Inferred from genetic interaction
15843532 MGI
acts upstream of or within cell population proliferation IDA
IDA: Inferred from direct assay
15843532 MGI
acts upstream of or within cell population proliferation IGI
IGI: Inferred from genetic interaction
15843532 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
12871593 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
18025219 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
18025219 MGI
acts upstream of or within defense response to protozoan IDA
IDA: Inferred from direct assay
19050265 MGI
acts upstream of or within defense response to protozoan IGI
IGI: Inferred from genetic interaction
9348310 MGI
acts upstream of or within defense response to protozoan IMP
IMP: Inferred from mutant phenotype
9348310 MGI
acts upstream of or within defense response to virus IDA
IDA: Inferred from direct assay
17277142 MGI
acts upstream of or within negative regulation of inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
16949315 MGI
involved in positive regulation of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
14688363 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
11057672 MGI
involved in positive regulation of T-helper 1 type immune response IDA
IDA: Inferred from direct assay
14688363 MGI
involved in positive regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
14688363 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
21444916 MGI
acts upstream of or within positive regulation of type II interferon production IGI
IGI: Inferred from genetic interaction
9348310 MGI
acts upstream of or within positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
16949315 MGI
acts upstream of type II interferon production IDA
IDA: Inferred from direct assay
21444916 MGI
acts upstream of type II interferon production IGI
IGI: Inferred from genetic interaction
9348310 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
20818394 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11737071 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
7690439 MGI
part of interleukin-12 complex IDA
IDA: Inferred from direct assay
15220916 MGI
part of interleukin-12 complex IGI
IGI: Inferred from genetic interaction
7690439 MGI
part of interleukin-23 complex IDA
IDA: Inferred from direct assay
11114383 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il12b Protein Structure

Ig_3

Ig_3: pfam13927 (31 - 89)

Ig

Ig: cd00096 (45 - 49)

Ig

Ig: cd00096 (55 - 59)

Ig

Ig: cd00096 (72 - 76)

IL12p40_C

IL12p40_C: pfam10420 (122 - 213)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
Protein Preferred Names Protein Names

interleukin-12 subunit beta

  • CLMF p40

  • IL-12 p40 subunit

  • IL-12 subunit p40

  • IL-23 subunit p40

  • cytotoxic lymphocyte maturation factor 40 kDa subunit

  • interleukin-12 p40 subunit

Recombinant Il12b Proteins

Cat. No. Product Name Accession Purity
HY-P7208 IL-12 Protein, Mouse (CHO) P43431 (R23-A215)&P43432 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70421 IL-23 Protein, Mouse (sf9) Q9EQ14 (V22-A196)&P43432 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70604 IL-23 Protein, Mouse (HEK293, C-His) Q9EQ14 (V22-A196)&P43432 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70666 IL-12 Protein, Mouse (HEK293) P43431 (R23-A215)&P43432 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70709 IL-23 Protein, Mouse (HEK293) Q9EQ14 (V22-A196)&P43432 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72597 IL-12 beta Protein, Mouse (HEK293, His) P43432 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73157 IL-12 Protein, Mouse (HEK293, Fc) P43431 (R23-A215)&P43432 (M23-S335) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P73158 IL-12 Protein, Mouse (HEK293, His-Fc) P43431 (R23-A215)&P43432 (M23-S335) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P73159 IL-12 Protein, Mouse (HEK293, His) P43431 (R23-A215)&P43432 (M23-S335) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73161 IL-12 beta Protein, Mouse (HEK293) P43432 (M23-S335) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P73162 IL-12 beta Protein, Mouse (HEK293, Fc) P43432 (M23-S335) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74874 Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His) Q9NPF7 (R20-P189)&P43432 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77703 Cynomolgus IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His) A0A2K5TLV4 (V22-P189)&P43432 (M23-S335) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77712 Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His-Avi) Q9NPF7 (R20-P189)&P43432 (M23-S335) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78152 IL-23 alpha Protein, Mouse (Biotinylated, HEK293, His-Avi) Q9EQ14 (V22-A196) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78861 IL-12 beta Protein, Mouse (Biotinylated, HEK293, His-Avi) P43432 (M23-S335) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74814 IL-23 Protein, Mouse (HEK293, His) Q9EQ14 (V22-A196)&P43432 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700191AF Animal-Free IL-12 beta Protein, Mouse (His) P43432 (M23-S335) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06680 IL12B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06681 Il12b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06682 Il12b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174617 Human IL23A mRNA / Unkown
HY-174641 Human IL12B mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il12b NCBI NCBI:3593