Il23a - interleukin 23, alpha subunit p19 Gene

Also Known as p19; IL-23

Species: Mus musculus

Gene Type: protein coding

Gene ID: 83430

About Il23a

Chromosome 10: 128,132,008-128,134,621 reverse strand.GRCm39:CM001003.3

This gene has 2 transcripts (splice variants), 96 orthologues and is associated with 30 phenotypes. Low expression observed in reference dataset.

Summary

Contributes to interleukin-23 receptor binding activity. Involved in positive regulation of defense response to virus by host; positive regulation of immune response; and positive regulation of neutrophil chemotaxis. Acts upstream of or within T cell proliferation and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Part of interleukin-23 complex. Is expressed in decidua; decidua basalis; embryo; and extraembryonic component. Orthologous to human IL23A (interleukin 23 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Il23a Products (1)

mRNA	Protein	Name
NM_031252.2	NP_112542.1	interleukin-23 subunit alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to interleukin-23 receptor binding	IPI IPI: Inferred from physical interaction	11114383	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11114383	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T cell proliferation	IDA IDA: Inferred from direct assay	16982811	MGI
involved in positive regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	14688363	MGI
involved in positive regulation of T-helper 1 type immune response	IDA IDA: Inferred from direct assay	14688363	MGI
involved in positive regulation of T-helper 17 cell lineage commitment	IDA IDA: Inferred from direct assay	19501566	MGI
involved in positive regulation of T-helper 17 type immune response	IDA IDA: Inferred from direct assay	19501566	MGI
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	14688363	MGI
involved in positive regulation of memory T cell differentiation	IDA IDA: Inferred from direct assay	14688363	MGI
involved in positive regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	19289819	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19666510	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	21148126	MGI
part of interleukin-23 complex	IDA IDA: Inferred from direct assay	11114383	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il23a Protein Structure

IL23

0
100
196 a.a.

Protein Preferred Names	Protein Names
interleukin-23 subunit alpha	IL-23 subunit alpha IL-23-A IL-23p19 interleukin-23 subunit p19

Il23a Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Il23a	Q9EQ14	Il12b	Mus musculus	P43432	Affinity Chrom	11114383
Intra	Il23a	Q9EQ14	Il12b	Mus musculus	P43432	Anti Bait CoIP	11114383

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Il23a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70421	IL-23 Protein, Mouse (sf9)	Q9EQ14 (V22-A196)&P43432 (M23-S335)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70604	IL-23 Protein, Mouse (HEK293, C-His)	Q9EQ14 (V22-A196)&P43432 (M23-S335)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70709	IL-23 Protein, Mouse (HEK293)	Q9EQ14 (V22-A196)&P43432 (M23-S335)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78152	IL-23 alpha Protein, Mouse (Biotinylated, HEK293, His-Avi)	Q9EQ14 (V22-A196)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P74814	IL-23 Protein, Mouse (HEK293, His)	Q9EQ14 (V22-A196)&P43432 (M23-S335)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990057	Picankibart	Inhibitor	98.00%	Phase 3

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176535	KB-0118	Inhibitor	/	Unkown
HY-RS06739	IL23A Human Pre-designed siRNA Set A		/	Unkown
HY-RS06740	Il23a Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS06741	Il23a Rat Pre-designed siRNA Set A		/	Unkown
HY-174616	Human IL23R mRNA		/	Unkown
HY-174617	Human IL23A mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il23a	NCBI	NCBI:51561