Kalrn - kalirin, RhoGEF kinase Gene

Also Known as DUET; TRAD; Gm539; Hapip; 2210407G14Rik; E530005C20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 545156

Summary

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and modulation of chemical synaptic transmission. Located in postsynaptic density. Is expressed in dorsal root ganglion and spinal cord. Orthologous to human KALRN (kalirin RhoGEF kinase). [provided by Alliance of Genome Resources, Apr 2022]

Kalrn Products (2)

mRNA Protein Name
NM_001164268.1 NP_001157740.1 kalirin isoform 2
NM_177357.3 NP_796331.2 kalirin isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
23116210 MGI
acts upstream of or within habituation IMP
IMP: Inferred from mutant phenotype
23116210 MGI
acts upstream of or within lactation IMP
IMP: Inferred from mutant phenotype
23116210 MGI
acts upstream of or within maternal behavior IMP
IMP: Inferred from mutant phenotype
23116210 MGI
acts upstream of or within maternal process involved in parturition IMP
IMP: Inferred from mutant phenotype
23116210 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
19625617 MGI
acts upstream of or within negative regulation of growth hormone secretion IMP
IMP: Inferred from mutant phenotype
23116210 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
23116210 MGI
acts upstream of or within positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
19625617 MGI
acts upstream of or within positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
19625617 MGI
acts upstream of or within social behavior IMP
IMP: Inferred from mutant phenotype
19625617 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kalirin

  • huntingtin-associated protein interacting protein (duo)

  • protein Duo

  • serine/threonine kinase with Dbl- and pleckstrin homology domain

  • serine/threonine kinase with Dbl- and pleckstrin homology domains

  • serine/threonine-protein kinase with Dbl- and plecks

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07062 KALRN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kalrn NCBI NCBI:8997