KALRN - kalirin RhoGEF kinase Gene

Homo sapiens

Also known as DUO; CHD5; DUET; TRAD; CHDS5; HAPIP; ARHGEF24

Gene ID: 8997 | Gene type: protein coding

About KALRN

Cytogenetic location: 3q21.1-q21.2 Genomic coordinates (GRCh38): 3:124,033,369-124,726,325 (from NCBI)

Broad expression in brain (RPKM 3.5), small intestine (RPKM 1.5) and 20 other tissues.

Summary

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein Huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a Huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]

KALRN Products(25)

mRNA	Protein	Name
NM_001024660.5	NP_001019831.2	kalirin isoform 1
NM_001322988.2	NP_001309917.1	kalirin isoform 4
NM_001322989.2	NP_001309918.1	kalirin isoform 5
NM_001322990.2	NP_001309919.1	kalirin isoform 6
NM_001322991.2	NP_001309920.1	kalirin isoform 7
NM_001322992.2	NP_001309921.1	kalirin isoform 8
NM_001322993.2	NP_001309922.1	kalirin isoform 9
NM_001322994.2	NP_001309923.1	kalirin isoform 10
NM_001322995.2	NP_001309924.1	kalirin isoform 11
NM_001322996.2	NP_001309925.1	kalirin isoform 12
NM_001322997.2	NP_001309926.1	kalirin isoform 13
NM_001322998.2	NP_001309927.1	kalirin isoform 14
NM_001322999.2	NP_001309928.1	kalirin isoform 15
NM_001323000.2	NP_001309929.1	kalirin isoform 16
NM_001323001.2	NP_001309930.1	kalirin isoform 17
NM_001388412.1	NP_001375341.1	kalirin isoform 18
NM_001388413.1	NP_001375342.1	kalirin isoform 19
NM_001388414.1	NP_001375343.1	kalirin isoform 20
NM_001388415.1	NP_001375344.1	kalirin isoform 21
NM_001388416.1	NP_001375345.1	kalirin isoform 22
NM_001388417.1	NP_001375346.1	kalirin isoform 23
NM_001388418.1	NP_001375347.1	kalirin isoform 24
NM_001388419.1	NP_001375348.1	kalirin isoform 25
NM_003947.6	NP_003938.1	kalirin isoform 2
NM_007064.5	NP_008995.2	kalirin isoform 3

KALRN Protein Structure

CRAL_TRIO_2

Spectrin

RhoGEF

0
300
600
900
1200
1500
1663 a.a.

Protein Preferred Names

Protein Names

kalirin

huntingtin-associated protein interacting protein (duo)

Related Diseases

Diseases

Alias

Coronary Heart Disease 5

Coronary Heart Disease, Susceptibility To, 5	CHDS5
Coronary Artery Disease, Early-Onset	Coronary Artery Disease Early-Onset
Early-Onset Coronary Artery Disease	Heart, Coronary, Disease, Susceptibility To, Type 5

Schizophrenia 1

SCZD1	Schizophrenia Susceptibility Locus, Chromosome 5-Related
Schizophrenia 1 With Or Without An Affective Disorder

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07062	KALRN Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KALRN	MGD	MGI:2685385
Felis catus	KALRN	VGNC	VGNC:102762
Bos taurus	KALRN	VGNC	VGNC:30389
Canis familiaris	KALRN	VGNC	VGNC:42200
Macaca mulatta	KALRN	VGNC	VGNC:84161
Rattus norvegicus	KALRN	RGD	RGD:621865

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