Syt7 - synaptotagmin VII Gene

Also Known as B230112P13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54525

Summary

Enables SNARE binding activity; Calmodulin binding activity; and phospholipid binding activity. Involved in several processes, including calcium-ion regulated exocytosis; regulation of secretion by cell; and regulation of vesicle-mediated transport. Acts upstream of or within plasma membrane repair. Located in several cellular components, including GABA-ergic synapse; cytoplasmic vesicle; and presynaptic membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SYT7 (synaptotagmin 7). [provided by Alliance of Genome Resources, Apr 2022]

Syt7 Products (4)

mRNA Protein Name
NM_001373944.1 NP_001360873.1 synaptotagmin-7 isoform 4
NM_018801.3 NP_061271.1 synaptotagmin-7 isoform alpha
NM_173067.3 NP_775090.1 synaptotagmin-7 isoform beta
NM_173068.2 NP_775091.2 synaptotagmin-7 isoform gamma

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IDA
IDA: Inferred from direct assay
12860971 MGI
enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
16982801 MGI
enables calmodulin binding IDA
IDA: Inferred from direct assay
24569478 MGI
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
12860971 MGI
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
12860971 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21041449 MGI
Biological Process GO Annotation Evidence References Source
involved in calcium ion regulated lysosome exocytosis IMP
IMP: Inferred from mutant phenotype
16982801 MGI
involved in calcium ion-regulated exocytosis of neurotransmitter IMP
IMP: Inferred from mutant phenotype
26738595 MGI
involved in calcium-dependent activation of synaptic vesicle fusion IDA
IDA: Inferred from direct assay
24267651 MGI
involved in calcium-dependent activation of synaptic vesicle fusion IMP
IMP: Inferred from mutant phenotype
24267651 MGI
involved in phagocytosis IMP
IMP: Inferred from mutant phenotype
21041449 MGI
involved in phagosome-lysosome fusion IMP
IMP: Inferred from mutant phenotype
16982801 MGI
acts upstream of or within plasma membrane repair IDA
IDA: Inferred from direct assay
12925704 MGI
involved in regulation of bone remodeling IMP
IMP: Inferred from mutant phenotype
18539119 MGI
involved in regulation of calcium ion-dependent exocytosis IMP
IMP: Inferred from mutant phenotype
12860971 MGI
involved in regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
21576241 MGI
involved in regulation of glucagon secretion IMP
IMP: Inferred from mutant phenotype
19171650 MGI
involved in regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
18308938 MGI
involved in regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
16982801 MGI
involved in short-term synaptic potentiation IDA
IDA: Inferred from direct assay
26738595 MGI
involved in short-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
24569478 MGI
involved in synaptic vesicle recycling IMP
IMP: Inferred from mutant phenotype
24569478 MGI
involved in vesicle-mediated cholesterol transport IDA
IDA: Inferred from direct assay
25860611 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
24267651 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
24267651 MGI
located in axon terminus IDA
IDA: Inferred from direct assay
21576241 MGI
located in dendrite IDA
IDA: Inferred from direct assay
21576241 MGI
located in early phagosome IDA
IDA: Inferred from direct assay
16982801 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24267651 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
24267651 MGI
located in lysosome IDA
IDA: Inferred from direct assay
12925704 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
21576241 MGI
located in peroxisome IDA
IDA: Inferred from direct assay
25860611 MGI
located in presynaptic membrane IDA
IDA: Inferred from direct assay
11395007 MGI
located in synaptic vesicle IMP
IMP: Inferred from mutant phenotype
24569478 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptotagmin-7

  • sytVII

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14119 SYT7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20823 Syt7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27337 Syt7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syt7 NCBI NCBI:9066