SYT7 - synaptotagmin 7 Gene

Also Known as IPCA7; IPCA-7; SYTVII; PCANAP7; SYT-VII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9066

About SYT7

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,513,714-61,588,387 (from NCBI)

This gene has 10 transcripts (splice variants), 266 orthologues and 31 paralogues. Biased expression in brain (RPKM 15.4), prostate (RPKM 13.8) and 12 other tissues.

Summary

This gene is a member of the synaptotagmin gene family and encodes a protein similar to Other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

SYT7 Products (7)

mRNA Protein Name
NM_001252065.2 NP_001238994.1 synaptotagmin-7 isoform 1
NM_001300773.2 NP_001287702.1 synaptotagmin-7 isoform 3
NM_001365809.2 NP_001352738.1 synaptotagmin-7 isoform 4
NM_001370210.1 NP_001357139.1 synaptotagmin-7 isoform 5
NM_001370211.1 NP_001357140.1 synaptotagmin-7 isoform 6
NM_001411007.1 NP_001397936.1 synaptotagmin-7 isoform 7
NM_004200.4 NP_004191.2 synaptotagmin-7 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYT7 Protein Structure

C2

C2: C2 domain (152 - 238)

C2

C2: C2 domain (285 - 370)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

synaptotagmin-7

  • prostate cancer-associated protein 7

SYT7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SYT7 O43581 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
Intra
SYT7 O43581 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Mucolipidosis
Peroxisome Biogenesis Disorder 1b

  • Peroxisome Biogenesis Disorder

  • Infantile Refsum Disease

  • Infantile Phytanic Acid Storage Disease

  • PBD1B

  • Refsum Disease, Infantile

  • Adrenoleukodystrophy, Autosomal Neonatal

  • Ird

  • Mild Pbd-Zsd

  • Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

  • Pbd-Zsd

  • Peroxisome Biogenesis Disorder Spectrum

  • Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

  • Autosomal Neonatal Adrenoleukodystrophy

  • Refsum Disease Infantile

  • Peroxisome Biogenesis Disorders

  • Peroxisome Biogenesis Disorder, Type 1b
Zellweger Syndrome

  • Cerebrohepatorenal Syndrome

  • Zellweger Leukodystrophy

  • Zs

  • Congenital Iron Overload

  • Chr

  • Zws

  • Severe Pbd-Zsd

  • Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14119 SYT7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20823 Syt7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27337 Syt7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SYT7 VGNC VGNC:65902
Mus musculus SYT7 MGD MGI:1859545
Bos taurus SYT7 VGNC VGNC:56283
Rattus norvegicus SYT7 RGD RGD:62013
Macaca mulatta SYT7 VGNC VGNC:101406
Canis familiaris SYT7 VGNC VGNC:47050
Others SYT7 NCBI