Cadm1 - cell adhesion molecule 1 Gene

Also Known as Bl2; ST17; Igsf4; Necl2; RA175; Tslc1; Igsf4a; RA175A; RA175B; RA175C; RA175N; SgIGSF; SynCam; 2900073G06Rik; 3100001I08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54725

Summary

Enables PDZ domain binding activity; protein homodimerization activity; and signaling receptor binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and synapse organization. Acts upstream of or within bone development; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; and unidimensional cell growth. Located in several cellular components, including basolateral plasma membrane; cell body fiber; and varicosity. Is integral component of postsynaptic membrane. Is active in Schaffer collateral - CA1 synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including nervous system; respiratory system; sensory organ; tooth; and urinary system. Human ortholog(s) of this gene implicated in breast carcinoma and prostate Cancer. Orthologous to human CADM1 (cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Cadm1 Products (5)

mRNA Protein Name
NM_001025600.1 NP_001020771.1 cell adhesion molecule 1 isoform d precursor
NM_001310841.1 NP_001297770.1 cell adhesion molecule 1 isoform e precursor
NM_018770.3 NP_061240.3 cell adhesion molecule 1 isoform c precursor
NM_207675.2 NP_997558.2 cell adhesion molecule 1 isoform a precursor
NM_207676.2 NP_997559.1 cell adhesion molecule 1 isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
12826663 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12202822 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
12826663 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
15811952 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
22876197 MGI
acts upstream of or within calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
IDA: Inferred from direct assay
12202822 MGI
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
12202822 MGI
involved in cell recognition IDA
IDA: Inferred from direct assay
15811952 MGI
involved in detection of stimulus IDA
IDA: Inferred from direct assay
15811952 MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
12826663 MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
IMP: Inferred from mutant phenotype
24687959 MGI
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
12826663 MGI
involved in lymphocyte migration into lymphoid organs IMP
IMP: Inferred from mutant phenotype
24687959 MGI
involved in maintenance of postsynaptic specialization structure IDA
IDA: Inferred from direct assay
21145003 MGI
involved in maintenance of postsynaptic specialization structure IMP
IMP: Inferred from mutant phenotype
21145003 MGI
involved in positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
15811952 MGI
involved in presynapse assembly IDA
IDA: Inferred from direct assay
12202822 MGI
involved in presynapse assembly IMP
IMP: Inferred from mutant phenotype
12202822 MGI
involved in retrograde trans-synaptic signaling by trans-synaptic protein complex IDA
IDA: Inferred from direct assay
23209303 MGI
involved in retrograde trans-synaptic signaling by trans-synaptic protein complex IMP
IMP: Inferred from mutant phenotype
23209303 MGI
involved in susceptibility to natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
15811952 MGI
acts upstream of or within synapse assembly IDA
IDA: Inferred from direct assay
12202822 MGI
involved in synapse assembly IDA
IDA: Inferred from direct assay
21145003 MGI
involved in synapse assembly IMP
IMP: Inferred from mutant phenotype
21145003 MGI
involved in synaptic membrane adhesion IDA
IDA: Inferred from direct assay
18003830 MGI
involved in synaptic membrane adhesion IEP
IEP: Inferred from expression pattern
18003830 MGI
acts upstream of or within unidimensional cell growth IMP
IMP: Inferred from mutant phenotype
18055550 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
21145003 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
21145003 MGI
located in axon IDA
IDA: Inferred from direct assay
15707673 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
12826663 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
12826663 MGI
located in dendrite IDA
IDA: Inferred from direct assay
15707673 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12202822 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
12202822 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15707673 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
26687224 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
26687224 MGI
located in synapse IDA
IDA: Inferred from direct assay
12202822 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
12202822 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cell adhesion molecule 1

  • NECL-2

  • TSLC-1

  • immunoglobulin superfamily member 4

  • immunoglobulin superfamily member 4A

  • immunosuperfamily protein Bl2

  • nectin-like 2

  • nectin-like protein 2

  • spermatogenic immunoglobulin superfamily

  • synaptic cell adhesion molecule

  • tumor suppressor in

Recombinant Cadm1 Proteins

Cat. No. Product Name Accession Purity
HY-P70085 CADM1/IGSF4A Protein, Mouse (HEK293, His) Q8R5M8-1 (Q48-H388) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75598 CADM1/IGSF4A Protein, Mouse (Q8R5M8-2, HEK293, His) Q8R5M8-2 (Q48-H377) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS17973 Cadm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01819 CADM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24444 Cadm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cadm1 NCBI NCBI:23705