AVPR1B - arginine vasopressin receptor 1B Gene

Homo sapiens

Also known as V1bR; VPR3; AVPR3

Gene ID: 553 | Gene type: protein coding

About AVPR1B

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,106,936-206,117,388 (from NCBI)

This gene has 2 transcripts (splice variants), 132 orthologues and 16 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]

AVPR1B Products(1)

mRNA	Protein	Name
NM_000707.5	NP_000698.1	vasopressin V1b receptor

AVPR1B Protein Structure

7tm_1

0
100
200
300
400
424 a.a.

Protein Preferred Names

Protein Names

vasopressin V1b receptor

AVPR V1b	AVPR V3
V1B receptor	antidiuretic hormone receptor 1B
arginine vasopressin receptor 3	pituitary vasopressin receptor 3
vasopressin V3 receptor

Related Diseases

Diseases

Alias

Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus	Diabetes Insipidus, Nephrogenic
Diabetes Insipidus Nephrogenic	Congenital Nephrogenic Diabetes Insipidus
Adh Resistant Diabetes Insipidus	Diabetes Insipidus Nephrogenic X-Linked
Diabetes Insipidus Nephrogenic Type 1	Adh-Resistant Diabetes Insipidus
Diabetes Insipidus Renalis	Ndi
Renal Diabetes Insipidus	Familial Nephrogenic Diabetes
Antidiuretic-Hormone-Resistant Diabetes Insipidus	Adiuretin-Resistant Diabetes Insipidus
Ndi - [Nephrogenic Diabetes Insipidus]	Diabetes Tenuifluus
Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus	Hereditary Nephrogenic Diabetes Insipidus
Familial Nephrogenic Diabetes Insipidus	Primary Nephrogenic Diabetes Insipidus

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Diabetes Insipidus

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Adrenal Cortex Adenoma	Corticotroph Pituitary Adenoma
Cushing'S Disease	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Asperger Syndrome

Asperger Disorder

Diabetes Insipidus, Neurohypophyseal

Neurohypophyseal Diabetes Insipidus	Central Diabetes Insipidus
Cdi	Pituitary Diabetes Insipidus
Vasopressin Defective Diabetes Insipidus	Vasopressin Deficiency
Diabetes Insipidus, Neurogenic	Diabetes Insipidus, Primary Central
Diabetes Insipidus, Cranial Type	Diabetes Insipidus Secondary To Vasopressin Deficiency
Diabetes Insipidus, Central	Diabetes Insipidus, Pituitary
NDI	Diabetes Insipidus Cranial Type
Neurogenic Diabetes Insipidus	Primary Central Diabetes Insipidus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0049A	Argipressin diacetate		/	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS01284	AVPR1B Human Pre-designed siRNA Set A	/	Unkown
HY-RS01285	Avpr1b Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS01286	Avpr1b Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AVPR1B	VGNC	VGNC:38319
Macaca mulatta	AVPR1B	VGNC	VGNC:70198
Rattus norvegicus	AVPR1B	RGD	RGD:6502812
Felis catus	AVPR1B	VGNC	VGNC:68844
Mus musculus	AVPR1B	MGD	MGI:1347010
Bos taurus	AVPR1B	VGNC	VGNC:26359
Others	AVPR1B	NCBI

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