MAML3 - mastermind like transcriptional coactivator 3 Gene

Homo sapiens

Also known as GDN; MAM2; CAGH3; ERDA3; MAM-2; TNRC3; mam-3

Gene ID: 55534 | Gene type: protein coding

About MAML3

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,716,753-140,154,184 (from NCBI)

This gene has 2 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 4.8), endometrium (RPKM 4.6) and 25 other tissues.

Summary

Enables transcription coactivator activity. Involved in Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

MAML3 Products(1)

mRNA	Protein	Name
NM_018717.5	NP_061187.3	mastermind-like protein 3

MAML3 Protein Structure

MamL-1

0
200
400
600
800
1000
1138 a.a.

Protein Preferred Names

Protein Names

mastermind-like protein 3

CAG repeat containing (glia-derived nexin I alpha)

Related Diseases

Diseases

Alias

Schneiderian Carcinoma

Cylindrical Cell Carcinoma

Ossifying Fibromyxoid Tumor

Ossifying Fibromyxoid Tumour

Ossifying Fibromyxoma

Lipofibromatosis-Like Neural Tumor

Adult Fibrosarcoma

Microphthalmia, Syndromic 2

Oculofaciocardiodental Syndrome	Ofcd Syndrome
MCOPS2	Microphthalmia, Cataracts, Radiculomegaly, And Septal Heart Defects
Syndromic Microphthalmia 2	Anop2
Cataract-Microphthalmia-Radiculomegaly-Cardiac Septal Defect Syndrome	Maa2
Microphthalmia Cataracts Radiculomegaly And Septal Heart Defects	Syndromic Microphthalmia Type 2
Oculo-Facio-Cardio-Dental Syndrome	Anop2, Formerly
Maa2, Formerly	Microphthalmia Syndromic 2
Oculo Facio Cardio Dental Syndrome	Microphthalmia, Syndromic, 2
Marashi-Gorlin Syndrome	Microphthalmia, Cataracts, Radiculomegaly And Septal Heart Defects
Microphthalmia, Syndromic, Type 2

Persistent Generalized Lymphadenopathy

Pgl	Persistant Generalized Lymphadenopathy

Kidney Clear Cell Sarcoma

Clear Cell Sarcoma Of Kidney	Childhood Kidney Clear Cell Sarcoma
Renal Clear Cell Sarcoma	Ccsk
Clear Cell Sarcoma Of The Kidney

Spindle Cell Rhabdomyosarcoma

Adenoid Cystic Carcinoma

Adenocystic Carcinoma	Cribriform Carcinoma
Cylindroma	Carcinoma Adenoid Cystic
Carcinoma, Adenoid Cystic	Adenoid Cystic Carcinoma Of Salivary Gland
Eccrine Dermal Cylindroma	Carcinoma, Cribriform

Malignant Triton Tumor

Malignant Peripheral Nerve Sheath Neoplasm With Rhabdomyosarcoma	Malignant Triton Tumour
Mpnst With Rhabdomyoblastic Differentiation	Mpnst With Rhabdomyosarcoma
Mpnst With Rhabdomyosarcomatous Differentiation	Mtt
Malignant Peripheral Nerve Sheath Tumor With Rhabdomyosarcomatous Differenciation	Malignant Peripheral Nerve Sheath Tumor With Rhabdomyoblastic Differentiation

Endometrial Stromal Tumor

Endometrial Stromal Neoplasm

Endometrial Stromal Tumors

Spindle Cell Sarcoma

Sarcoma	Sarcoma Spindle Cell
Sarcoma, Spindle Cell	Sarcoma - Category

Endometrial Stromal Sarcoma

Ess	Endometrial Stromal Sarcoma, High Grade
Undifferentiated Endometrial Sarcoma	Stromal Sarcoma Of The Corpus Uteri
Sarcoma Endometrial Stromal	Sarcoma, Endometrial Stromal
Undifferentiated Stromal Sarcoma

Enchondromatosis, Multiple, Ollier Type

Ollier Disease	Enchondromatosis
Dyschondroplasia	Osteochondromatosis
Multiple Cartilaginous Enchondroses	Multiple Enchondromatosis
Enchondromatosis With Haemangiomata	Enchondromatosis, Multiple
Kast'S Syndrome	Ollier'S Syndrome
Enchondromatosis Multiple	ENCHOM
Maffucci Disease	Olliers Disease
Hereditary Multiple Exostoses	Chondromatosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08001	MAML3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAML3	RGD	RGD:1308177
Canis familiaris	MAML3	VGNC	VGNC:50422
Bos taurus	MAML3	VGNC	VGNC:53912
Mus musculus	MAML3	MGD	MGI:2389461
Macaca mulatta	MAML3	VGNC	VGNC:74298
Felis catus	MAML3	VGNC	VGNC:107343

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