KANSL3 - KAT8 regulatory NSL complex subunit 3 Gene

Also Known as NSL3; Rcd1; KIAA1310

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55683

About KANSL3

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,580,494-96,638,312 (from NCBI)

This gene has 21 transcripts (splice variants), 203 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 20.0), ovary (RPKM 12.2) and 25 other tissues.

Summary

Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in nucleoplasm. Part of Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

KANSL3 Products (8)

mRNA	Protein	Name
NM_001115016.3	NP_001108488.1	KAT8 regulatory NSL complex subunit 3 isoform 1
NM_001349256.2	NP_001336185.1	KAT8 regulatory NSL complex subunit 3 isoform 2
NM_001349257.2	NP_001336186.1	KAT8 regulatory NSL complex subunit 3 isoform 3
NM_001349258.2	NP_001336187.1	KAT8 regulatory NSL complex subunit 3 isoform 4
NM_001349259.2	NP_001336188.1	KAT8 regulatory NSL complex subunit 3 isoform 5
NM_001349260.2	NP_001336189.1	KAT8 regulatory NSL complex subunit 3 isoform 6
NM_001349261.2	NP_001336190.1	KAT8 regulatory NSL complex subunit 3 isoform 7
NM_001349262.2	NP_001336191.1	KAT8 regulatory NSL complex subunit 3 isoform 7

KANSL3 Protein Structure

Abhydrolase_5

0
200
400
600
800
878 a.a.

Protein Preferred Names	Protein Names
KAT8 regulatory NSL complex subunit 3	NSL complex protein NSL3

KANSL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KANSL3	Q9P2N6	PHF20	Homo sapiens	Q9BVI0	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mixed Cerebral Palsy	Cerebral Palsy, Mixed
Maxillonasal Dysplasia, Binder Type	Binder Syndrome Binder Type Maxillonasal Dysplasia Maxillonasal Dysplasia Maxillonasal Dysostosis
Nodular Ganglioneuroblastoma	Ganglioneuroblastoma, Nodular
Discitis
Osteogenesis Imperfecta, Type Iv	Osteogenesis Imperfecta Type 4 Osteogenesis Imperfecta Type Iv OI4 Oi, Type Iv Osteogenesis Imperfecta With Normal Sclerae Oi Type Iv Oi Type 4 Osteogenesis Imperfecta With Normal Sclera Common Variable Oi With Normal Sclerae Osteogenesis Imperfecta 4 Oi-Iv
Osteogenesis Imperfecta, Type Iii	Osteogenesis Imperfecta Type Iii OI3 Oi, Type Iii Osteogenesis Imperfecta Type 3 Oi Type Iii Oi Type 3 Progressive Deforming Osteogenesis Imperfecta Severe Osteogenesis Imperfecta Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae Progressively Deforming Osteogenesis Imperfecta With Normal Sclera Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae Progressively Deforming Oi Osteogenesis Imperfecta 3 Oi-Iii Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07069	KANSL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KANSL3	RGD	RGD:1309220
Mus musculus	KANSL3	MGD	MGI:1918055
Felis catus	KANSL3	VGNC	VGNC:63021
Macaca mulatta	KANSL3	VGNC	VGNC:73907
Canis familiaris	KANSL3	VGNC	VGNC:42206
Bos taurus	KANSL3	VGNC	VGNC:30395
Others	KANSL3	NCBI