MINDY1 - MINDY lysine 48 deubiquitinase 1 Gene

Also Known as FAM63A; MINDY-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55793

About MINDY1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,996,536-151,008,393 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 17.7), testis (RPKM 8.4) and 25 other tissues.

Summary

Enables K48-linked polyubiquitin modification-dependent protein binding activity; Lys48-specific Deubiquitinase activity; and cysteine-type Carboxypeptidase activity. Predicted to be involved in protein K48-linked deubiquitination. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

MINDY1 Products (17)

mRNA Protein Name
NM_001040217.3 NP_001035307.2 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 2
NM_001163258.3 NP_001156730.3 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 1
NM_001163259.2 NP_001156731.2 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 4
NM_001163260.2 NP_001156732.2 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 2
NM_001319998.2 NP_001306927.2 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 1
NM_001376664.1 NP_001363593.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 5
NM_001376665.1 NP_001363594.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 1
NM_001376666.1 NP_001363595.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 7
NM_001376667.1 NP_001363596.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 8
NM_001376668.1 NP_001363597.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 8
NM_001376669.1 NP_001363598.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 9
NM_001376670.1 NP_001363599.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 10
NM_001376671.1 NP_001363600.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 11
NM_001376672.1 NP_001363601.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 12
NM_001376673.1 NP_001363602.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 12
NM_001376674.1 NP_001363603.1 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 13
NM_018379.5 NP_060849.3 ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables K48-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
27292798 GOA
enables K48-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
28082312 GOA
enables cysteine-type carboxypeptidase activity IDA
IDA: Inferred from direct assay
27292798 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MINDY1 Protein Structure

MINDY_DUB

MINDY_DUB: MINDY deubiquitinase (143 - 268)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase MINDY-1

  • MINDY deubiquitinase 1

MINDY1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MINDY1 Q8N5J2 FLJ13057 Homo sapiens Q53SE7
Y2H Prey Pooling
25416956
Intra
MINDY1 Q8N5J2 FLJ13057 Homo sapiens Q53SE7
Y2H Array
25416956
Intra
MINDY1 Q8N5J2 FLJ13057 Homo sapiens Q53SE7
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nipah Virus Encephalitis

  • Equine Morbillivirus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08451 MINDY1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MINDY1 VGNC VGNC:63510
Bos taurus MINDY1 VGNC VGNC:55615
Mus musculus MINDY1 MGD MGI:1922257
Canis familiaris MINDY1 VGNC VGNC:43236
Macaca mulatta MINDY1 VGNC VGNC:74828
Rattus norvegicus MINDY1 RGD RGD:1559660
Others MINDY1 NCBI