Ddx21 - DExD box helicase 21 Gene

Also Known as D10Wsu42e; D10Ertd645e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56200

Summary

Enables double-stranded RNA binding activity and identical protein binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of myeloid dendritic cell cytokine production. Acts upstream of or within response to exogenous dsRNA and response to virus. Located in cytosol. Is expressed in several structures, including 1st branchial arch; early conceptus; genitourinary system; and limb. Orthologous to human DDX21 (DExD-box helicase 21). [provided by Alliance of Genome Resources, Apr 2022]

Ddx21 Products (1)

mRNA Protein Name
NM_019553.2 NP_062426.2 nucleolar RNA helicase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
21703541 MGI
enables identical protein binding IDA
IDA: Inferred from direct assay
21703541 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21703541 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
21703541 MGI
involved in positive regulation of myeloid dendritic cell cytokine production IMP
IMP: Inferred from mutant phenotype
21703541 MGI
acts upstream of or within response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
21703541 MGI
acts upstream of or within response to virus IMP
IMP: Inferred from mutant phenotype
21703541 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
21703541 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleolar RNA helicase 2

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 21

  • DEAD box protein 21

  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 (RNA helicase II/Gu)

  • RH II/Gu

  • RH-II/Gualpha

  • gu-alpha

  • nucleolar RNA helicase Gu

  • nucleolar RNA helicase II

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175238 KI-DX-014 99.87% Unkown
HY-RS03637 DDX21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03661 DDX56 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20906 Ddx21 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27423 Ddx21 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddx21 NCBI NCBI:9188