Spen - spen family transcription repressor Gene

Also Known as Mint; mKIAA0929

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56381

Summary

Enables DNA-binding transcription factor activity; single-stranded DNA binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription, DNA-templated and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in central nervous system; genitourinary system; hemolymphoid system; sensory organ; and tooth. Orthologous to human SPEN (spen family transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]

Spen Products (2)

mRNA Protein Name
NM_001347235.1 NP_001334164.1 msx2-interacting protein isoform 2
NM_019763.2 NP_062737.2 msx2-interacting protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables DNA binding IDA
IDA: Inferred from direct assay
15778499 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10451362 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10451362 MGI
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
10451362 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
15778499 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10451362 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10451362 MGI
involved in random inactivation of X chromosome IMP
IMP: Inferred from mutant phenotype
25915022 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10451362 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

msx2-interacting protein

  • Msx2 interacting nuclear target protein

  • SMART/HDAC1-associated repressor protein

  • SPEN homolog, transcriptional regulator

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-152038 SPEN-IN-1 Inhibitor 97.25% Unkown
HY-RS13660 SPEN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11735 RBM15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20339 Spen Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26847 Spen Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spen NCBI NCBI:23013