Ncoa6 - nuclear receptor coactivator 6 Gene

Also Known as NRC; AIB3; ASC2; PRIP; ASC-2; Ncoa7; RAP250; mKIAA0181

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56406

Summary

Enables chromatin binding activity and transcription coactivator activity. Acts upstream of or within animal organ development; histone H3-K4 trimethylation; and positive regulation of transcription, DNA-templated. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung Cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Apr 2022]

Ncoa6 Products (4)

mRNA Protein Name
NM_001242558.2 NP_001229487.1 nuclear receptor coactivator 6 isoform 2
NM_001406325.1 NP_001393254.1 nuclear receptor coactivator 6 isoform 1
NM_001406326.1 NP_001393255.1 nuclear receptor coactivator 6 isoform 1
NM_019825.4 NP_062799.2 nuclear receptor coactivator 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
12446761 MGI
enables chromatin-protein adaptor activity IMP
IMP: Inferred from mutant phenotype
17021013 MGI
enables histone methyltransferase binding IPI
IPI: Inferred from physical interaction
17021013 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
10788465 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
12556486 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
12368298 MGI
acts upstream of or within labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
12368298 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10681503 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17021013 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10788465 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
10681503 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor coactivator 6

  • PPAR interacting protein PRIP

  • PPAR-interacting protein

  • activating signal cointegrator 2

  • amplified in breast cancer protein 3

  • cancer-amplified transcriptional coactivator ASC-2

  • nuclear receptor coactivator RAP250

  • nuclear receptor-activating protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09094 NCOA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20060 Ncoa6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26564 Ncoa6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncoa6 NCBI NCBI:23054