Ybx3 - Y box protein 3 Gene

Also Known as Yb2; Csda; Dpba; MSY3; MSY4; dbpA; oxyR

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56449

Summary

Enables nucleic acid binding activity and polysome binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including male gonad development; negative regulation of skeletal muscle tissue development; and positive regulation of organ growth. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; branchial arch; limb bud; sensory organ; and testis. Orthologous to human YBX3 (Y-box binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Ybx3 Products (2)

mRNA	Protein	Name
NM_011733.2	NP_035863.1	Y-box-binding protein 3 short isoform
NM_139117.2	NP_620817.2	Y-box-binding protein 3 long isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12433987	MGI
enables RNA binding	IDA IDA: Inferred from direct assay	12117816	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17934523	MGI
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	10772793	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19710015	MGI
enables ribonucleoprotein complex binding	IDA IDA: Inferred from direct assay	10772793	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	16954378	MGI
acts upstream of ectopic germ cell programmed cell death	IMP IMP: Inferred from mutant phenotype	16954378	MGI
acts upstream of or within fertilization	IMP IMP: Inferred from mutant phenotype	16954378	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	16954378	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	16954378	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16954378	MGI
acts upstream of or within negative regulation of developmental process	IMP IMP: Inferred from mutant phenotype	16954378	MGI
acts upstream of or within negative regulation of reproductive process	IMP IMP: Inferred from mutant phenotype	16954378	MGI
acts upstream of or within negative regulation of skeletal muscle tissue development	IDA IDA: Inferred from direct assay	18676817	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17934523	MGI
acts upstream of or within positive regulation of organ growth	IMP IMP: Inferred from mutant phenotype	16954378	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	16954378	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10772793	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12433987	MGI
is active in synapse	EXP EXP: Inferred from Experiment	25211037	MGI
is active in synapse	IDA IDA: Inferred from direct assay	25211037	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
Y-box-binding protein 3	DNA-binding protein A cold shock domain protein A cold shock domain-containing protein A

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15918	YBX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20351	Ybx3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26860	Ybx3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ybx3	NCBI	NCBI:8531