Clcf1 - cardiotrophin-like cytokine factor 1 Gene

Also Known as CLC; Bsf3; BSF-3; NNT-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56708

Summary

Enables cytokine activity. Involved in positive regulation of B cell activation; positive regulation of astrocyte differentiation; and positive regulation of tyrosine phosphorylation of STAT protein. Acts upstream of or within B cell differentiation and receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular space. Predicted to be part of CNTFR-CLCF1 complex and CRLF-CLCF1 complex. Predicted to be active in extracellular region. Is expressed in several structures, including alimentary system; central nervous system; lung; metanephros; and skeletal musculature. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 2. Orthologous to human CLCF1 (cardiotrophin like cytokine factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Clcf1 Products (3)

mRNA Protein Name
NM_001310038.3 NP_001296967.1 cardiotrophin-like cytokine factor 1 isoform 2 precursor
NM_001310039.2 NP_001296968.1 cardiotrophin-like cytokine factor 1 isoform 2 precursor
NM_019952.6 NP_064336.1 cardiotrophin-like cytokine factor 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
10500198 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21097510 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IDA
IDA: Inferred from direct assay
10500198 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
10500198 MGI
acts upstream of or within cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
10500198 MGI
involved in cell surface receptor signaling pathway via STAT IDA
IDA: Inferred from direct assay
12090754 MGI
involved in positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
12023368 MGI
involved in positive regulation of astrocyte differentiation IDA
IDA: Inferred from direct assay
12090754 MGI
involved in positive regulation of immunoglobulin production IDA
IDA: Inferred from direct assay
12023368 MGI
involved in positive regulation of isotype switching to IgE isotypes IDA
IDA: Inferred from direct assay
12023368 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cardiotrophin-like cytokine factor 1

  • B-cell stimulating factor 3

  • neurotrophin-1/B-cell stimulating factor-3

  • novel neurotrophin-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02752 CLCF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18058 Clcf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24533 Clcf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clcf1 NCBI NCBI:23529