CLCF1 - cardiotrophin like cytokine factor 1 Gene

Also Known as CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23529

About CLCF1

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,364,168-67,374,177 (from NCBI)

This gene has 2 transcripts (splice variants), 187 orthologues, 1 paralogue and is associated with 3 phenotypes. Broad expression in gall bladder (RPKM 9.3), endometrium (RPKM 7.5) and 21 other tissues.

Summary

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

CLCF1 Products (2)

mRNA Protein Name
NM_001166212.2 NP_001159684.1 cardiotrophin-like cytokine factor 1 isoform 2 precursor
NM_013246.3 NP_037378.1 cardiotrophin-like cytokine factor 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to ciliary neurotrophic factor receptor binding IDA
IDA: Inferred from direct assay
10966616 GOA
enables ciliary neurotrophic factor receptor binding IDA
IDA: Inferred from direct assay
11285233 GOA
contributes to cytokine activity IDA
IDA: Inferred from direct assay
10966616 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10966616 GOA
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
15272019 GOA
Biological Process GO Annotation Evidence References Source
involved in cell surface receptor signaling pathway via STAT IDA
IDA: Inferred from direct assay
10966616 GOA
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
10966616 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10966616 GOA
Cellular Component GO Annotation Evidence References Source
part of CNTFR-CLCF1 complex IDA
IDA: Inferred from direct assay
11285233 GOA
part of CRLF-CLCF1 complex IDA
IDA: Inferred from direct assay
10966616 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
10966616 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLCF1 Protein Structure

PRF

PRF: Plethodontid receptivity factor PRF (54 - 211)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

cardiotrophin-like cytokine factor 1

  • B-cell stimulatory factor 3

Related Diseases

Diseases Alias
Crisponi/Cold-Induced Sweating Syndrome 2

  • Cold-Induced Sweating Syndrome 2

  • CISS2

  • Sweating Syndrome, Cold-Induced, Type 2
Cold-Induced Sweating Syndrome

  • Crisponi Syndrome

  • Sohar-Crisponi Syndrome

  • Ciss

  • Cntf Receptor-Related Disorders

  • Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death

  • Sweating Syndrome, Cold-Induced
Crisponi/Cold-Induced Sweating Syndrome 1

  • Crisponi Syndrome

  • Cold-Induced Sweating Syndrome 1

  • CISS1

  • Sohar-Crisponi Syndrome

  • Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death

  • Muscle Contractions Tetanoform With Characteristic Face Camptodactyly Hyperthermia And Sudden Death
Developmental And Epileptic Encephalopathy 11

  • Epileptic Encephalopathy, Early Infantile, 11

  • DEE11

  • Eiee11

  • Developmental And Epileptic Encephalopathy, 11

  • Early Infantile Epileptic Encephalopathy 11

  • Encephalopathy, Developmental And Epileptic, Type 11
Congenital Contractures Of The Limbs And Face, Hypotonia, And Developmental Delay

  • CLIFAHDD

  • Congenital Limbs-Face Contractures-Hypotonia-Developmental Delay Syndrome

  • Clifahdd Syndrome

  • Doid:0081048

  • Contractures, Limbs And Face, Congenital, Hypotonia, And Developmental Delay
Arthrogryposis, Distal, Type 1a

  • Distal Arthrogryposis Type 1

  • Digitotalar Dysmorphism

  • DA1A

  • Da1

  • Amcd1

  • Arthrogryposis, Distal, Type 2b4

  • Distal Arthrogryposis Type 1a

  • Arthrogryposis, Distal, Type 1

  • Arthrogryposis Multiplex Congenita Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal, Type I

  • Distal Arthrogryposis Type 1b

  • Arthrogryposis, Distal, 1a

  • Amc

  • Arthrogryposis Multiplex Congenita

  • Arthrogryposis, Distal, 2b4

  • DA2B4

  • Arthrogryposis Multiplex Congenita, Distal, Type 1

  • Arthrogryposis
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02752 CLCF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18058 Clcf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24533 Clcf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLCF1 MGD MGI:1930088
Rattus norvegicus CLCF1 RGD RGD:1303171
Bos taurus CLCF1 VGNC VGNC:56260
Felis catus CLCF1 VGNC VGNC:60922
Macaca mulatta CLCF1 VGNC VGNC:71195
Canis familiaris CLCF1 VGNC VGNC:39300
Others CLCF1 NCBI