Litaf - LPS-induced TN factor Gene

Also Known as TBX1; N4WBP3; 3222402J11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56722

Summary

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; WW domain binding activity; and zinc ion binding activity. Acts upstream of or within cellular response to lipopolysaccharide; negative regulation of NIK/NF-kappaB signaling; and regulation of cytokine production. Predicted to be located in several cellular components, including cytoplasmic side of endosome membrane; cytoplasmic side of lysosomal membrane; and cytoplasmic side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; retina nuclear layer; and vibrissa. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1C. Orthologous to human LITAF (lipopolysaccharide induced TNF factor). [provided by Alliance of Genome Resources, Apr 2022]

Litaf Products (1)

mRNA Protein Name
NM_019980.2 NP_064364.1 lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
11042109 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of or within cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
16954198 MGI
acts upstream of or within negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
12914755 MGI
acts upstream of or within regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
16954198 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
22160695 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

  • LITAF-like protein

  • LPS-induced TNF-alpha factor homolog

  • Nedd4 WW domain-binding protein 3

  • estrogen-enhanced transcript protein

  • mEET

Litaf Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
Litaf Q9JLJ0 Nedd4 Mus musculus P46935
Affinity Techniques
11042109
Intra
Litaf Q9JLJ0 Nedd4 Mus musculus P46935
Far-WB
11042109
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS07697 LITAF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20980 Litaf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27497 Litaf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Litaf NCBI NCBI:9516