2. Gene
  3. ANKS1B - ankyrin repeat and sterile alpha motif domain containing 1B Gene

ANKS1B - ankyrin repeat and sterile alpha motif domain containing 1B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EB1; AIDA; EB-1; ANKS2; AIDA-1; cajalin-2

Gene ID: 56899 | Gene type: protein coding

About ANKS1B

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:98,734,786-99,984,936 (from NCBI)

This gene has 35 transcripts (splice variants), 244 orthologues and 1 paralogue. Broad expression in brain (RPKM 8.0), thyroid (RPKM 1.1) and 21 other tissues.

Summary

This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]

ANKS1B Products(52)

mRNA Protein Name
NM_001204065.2 NP_001190994.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform d
NM_001204066.2 NP_001190995.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform e
NM_001204067.2 NP_001190996.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform f
NM_001204068.2 NP_001190997.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform g
NM_001204069.2 NP_001190998.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform h
NM_001204070.2 NP_001190999.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform i
NM_001204079.2 NP_001191008.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform j
NM_001204080.2 NP_001191009.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform k
NM_001204081.2 NP_001191010.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform l
NM_001352185.1 NP_001339114.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform p
NM_001352186.2 NP_001339115.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform m
NM_001352187.1 NP_001339116.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform o
NM_001352188.1 NP_001339117.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform n
NM_001352189.1 NP_001339118.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform v
NM_001352190.1 NP_001339119.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform qq
NM_001352191.2 NP_001339120.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform ee
NM_001352192.2 NP_001339121.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform z
NM_001352193.2 NP_001339122.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform y
NM_001352194.2 NP_001339123.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform cc
NM_001352195.2 NP_001339124.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform r
NM_001352196.2 NP_001339125.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform s
NM_001352197.2 NP_001339126.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform w
NM_001352198.2 NP_001339127.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform q
NM_001352199.2 NP_001339128.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform aa
NM_001352200.2 NP_001339129.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform u
NM_001352201.2 NP_001339130.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform dd
NM_001352202.2 NP_001339131.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform pp
NM_001352203.2 NP_001339132.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform bb
NM_001352204.2 NP_001339133.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform t
NM_001352205.2 NP_001339134.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform oo
NM_001352206.2 NP_001339135.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform x
NM_001352207.2 NP_001339136.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform k
NM_001352208.2 NP_001339137.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform gg
NM_001352209.2 NP_001339138.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform ii
NM_001352210.2 NP_001339139.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform kk
NM_001352211.2 NP_001339140.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform ll
NM_001352212.2 NP_001339141.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform ll
NM_001352213.2 NP_001339142.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform nn
NM_001352214.2 NP_001339143.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform nn
NM_001352216.2 NP_001339145.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform nn
NM_001352217.2 NP_001339146.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform mm
NM_001352218.2 NP_001339147.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform ll
NM_001352219.2 NP_001339148.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform ff
NM_001352220.2 NP_001339149.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform ll
NM_001352221.2 NP_001339150.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform ii
NM_001352222.2 NP_001339151.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform gg
NM_001352223.2 NP_001339152.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform hh
NM_001352224.2 NP_001339153.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform ll
NM_001352225.2 NP_001339154.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform jj
NM_020140.4 NP_064525.1 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform c
NM_152788.4 NP_690001.3 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform a
NM_181670.4 NP_858056.2 ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform b

ANKS1B Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (7 - 88)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (96 - 187)

Ank_5

Ank_5: Ankyrin repeats (many copies) (213 - 265)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (811 - 873)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (884 - 943)

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (1062 - 1192)

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  • 1248 a.a.
Protein Preferred Names Protein Names

ankyrin repeat and sterile alpha motif domain-containing protein 1B

E2a-Pbx1-associated protein

Related Diseases

Diseases Alias
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Osteogenesis Imperfecta, Type Ix

Osteogenesis Imperfecta Type 9

Osteogenesis Imperfecta Type Ix

OI9

Oi Type Ix

Osteogenesis Imperfecta Sillence Type Ii/Iii Without Abnormality Of Type I Collagen

Oi, Type Ix

Oi 9

Osteogenesis Imperfecta 9

Oi-Ix
Supratentorial Meningioma
Avoidant Personality Disorder

Anxious Personality Disorder

Personality Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00736 ANKS1B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ANKS1B VGNC VGNC:83492
Canis familiaris ANKS1B VGNC VGNC:37917
Rattus norvegicus ANKS1B RGD RGD:1565556
Macaca mulatta ANKS1B VGNC VGNC:69689
Mus musculus ANKS1B MGD MGI:1924781