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PSMB5 - proteasome 20S subunit beta 5 Gene

Also Known as MB1; LMPX

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5693

About PSMB5

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,025,851-23,035,220 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 31.9), placenta (RPKM 30.5) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the Proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the Proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (Proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

PSMB5 Products (3)

mRNA	Protein	Name
NM_001130725.1	NP_001124197.1	proteasome subunit beta type-5 isoform 2
NM_001144932.3	NP_001138404.1	proteasome subunit beta type-5 isoform 3
NM_002797.5	NP_002788.1	proteasome subunit beta type-5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables peptidase activity	IDA IDA: Inferred from direct assay	17540904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14733938	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	17540904	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	34711951	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	34711951	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA
part of proteasome core complex	IDA IDA: Inferred from direct assay	34711951	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMB5 Protein Structure

Proteasome

0
100
200
263 a.a.

Protein Preferred Names	Protein Names
proteasome subunit beta type-5	PSX large multifunctional protease X

PSMB5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PSMB5	P28074	DUSP29	Homo sapiens	Q68J44	Y2H Prey Pooling	32296183
Intra	PSMB5	P28074	DUSP29	Homo sapiens	Q68J44	Validated Y2H	32296183
Intra	PSMB5	P28074	DUSP29	Homo sapiens	Q68J44	Y2H Array	32296183
Intra	PSMB5	P28074	CCDC150	Homo sapiens	Q8NCX0-3	Y2H Prey Pooling	32296183
Intra	PSMB5	P28074	CCDC150	Homo sapiens	Q8NCX0-3	Validated Y2H	32296183
Intra	PSMB5	P28074	CCDC150	Homo sapiens	Q8NCX0-3	Y2H Array	32296183
Intra	PSMB5	P28074	CLP1	Homo sapiens	Q92989	Validated Y2H	32296183
Intra	PSMB5	P28074	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	PSMB5	P28074	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	PSMB5	P28074	LSM1	Homo sapiens	O15116	Y2H Array	32296183
Intra	PSMB5	P28074	LSM1	Homo sapiens	O15116	Y2H Prey Pooling	32296183
Intra	PSMB5	P28074	PSMB1	Homo sapiens	P20618	Anti Tag CoIP	35271311
Intra	PSMB5	P28074	PSMB7	Homo sapiens	Q99436	Y2H	17948026
Intra	PSMB5	P28074	PSMB3	Homo sapiens	P49720	Y2H	14733938
Intra	PSMB5	P28074	POMP	Homo sapiens	Q9Y244	Y2H	14733938
Intra	PSMB5	P28074	POMP	Homo sapiens	Q9Y244	Y2H	17948026
Intra	PSMB5	P28074	POMP	Homo sapiens	Q9Y244	Anti Tag CoIP	35271311
Intra	PSMB5	P28074	TCHP	Homo sapiens	Q9BT92	Validated Y2H	32296183
Intra	PSMB5	P28074	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	PSMB5	P28074	IKBKG	Homo sapiens	Q9Y6K9	Y2H Prey Pooling	32296183
Intra	PSMB5	P28074	IKBKG	Homo sapiens	Q9Y6K9	Validated Y2H	32296183
Intra	PSMB5	P28074	IKBKG	Homo sapiens	Q9Y6K9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

PSMB5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83719	PSMB5/MB1 Antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170881	TIR-199	Inhibitor	/	Unkown
HY-RS11305	PSMB5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21701	Psmb5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28219	Psmb5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PSMB5	VGNC	VGNC:76445
Canis familiaris	PSMB5	VGNC	VGNC:45097
Bos taurus	PSMB5	VGNC	VGNC:33449
Felis catus	PSMB5	VGNC	VGNC:80876
Rattus norvegicus	PSMB5	RGD	RGD:61879
Mus musculus	PSMB5	MGD	MGI:1194513
Others	PSMB5	NCBI