PMEPA1 - prostate transmembrane protein, androgen induced 1 Gene

Also Known as STAG1; TMEPAI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56937

About PMEPA1

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:57,648,396-57,711,472 (from NCBI)

This gene has 8 transcripts (splice variants), 94 orthologues and 1 paralogue. Broad expression in prostate (RPKM 54.2), fat (RPKM 28.9) and 20 other tissues.

Summary

This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the Androgen Receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

PMEPA1 Products (5)

mRNA Protein Name
NM_001255976.2 NP_001242905.1 protein TMEPAI isoform d
NM_020182.5 NP_064567.2 protein TMEPAI isoform a
NM_199169.3 NP_954638.1 protein TMEPAI isoform b
NM_199170.3 NP_954639.1 protein TMEPAI isoform c precursor
NM_199171.3 NP_954640.1 protein TMEPAI isoform c precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables R-SMAD binding IPI
IPI: Inferred from physical interaction
20129061 GOA
enables WW domain binding IPI
IPI: Inferred from physical interaction
12907594 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24627487 GOA
enables protein sequestering activity IDA
IDA: Inferred from direct assay
20129061 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
24627487 GOA
involved in negative regulation of SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
20129061 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
24627487 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20129061 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
20129061 GOA
located in early endosome membrane IDA
IDA: Inferred from direct assay
24627487 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
20129061 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein TMEPAI

  • solid tumor-associated 1 protein

PMEPA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810991 PMEPA1 Antibody WB, IHC-P, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179123 ZC9 / Unkown
HY-RS10761 PMEPA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PMEPA1 RGD RGD:1308255
Mus musculus PMEPA1 MGD MGI:1929600
Canis familiaris PMEPA1 VGNC VGNC:44731
Macaca mulatta PMEPA1 VGNC VGNC:76023
Bos taurus PMEPA1 VGNC VGNC:33070
Felis catus PMEPA1 VGNC VGNC:64255
Others PMEPA1 NCBI