2. Gene
  3. PARP11 - poly(ADP-ribose) polymerase family member 11 Gene

PARP11 - poly(ADP-ribose) polymerase family member 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARTD11; MIB006; C12orf6

Gene ID: 57097 | Gene type: protein coding

About PARP11

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:3,808,861-3,873,399 (from NCBI)

This gene has 8 transcripts (splice variants), 259 orthologues and 8 paralogues. Ubiquitous expression in prostate (RPKM 3.6), testis (RPKM 3.6) and 25 other tissues.

Summary

Enables NAD+ ADP-ribosyltransferase activity and protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Located in cytosol; nuclear body; and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]

PARP11 Products(3)

mRNA Protein Name
NM_001286521.2 NP_001273450.1 protein mono-ADP-ribosyltransferase PARP11 isoform b
NM_001286522.2 NP_001273451.1 protein mono-ADP-ribosyltransferase PARP11 isoform b
NM_020367.6 NP_065100.2 protein mono-ADP-ribosyltransferase PARP11 isoform a

PARP11 Protein Structure

WWE

WWE: WWE domain (35 - 106)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (137 - 337)

  • 0
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  • 300
  • 338 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP11

ADP-ribosyltransferase diphtheria toxin-like 11

Related Diseases

Diseases Alias
Osteogenesis Imperfecta, Type Xx

OI20

Osteogenesis Imperfecta Type 20

Osteogenesis Imperfecta, Type 20

Osteogenesis Imperfecta Type Xx

Osteogenesis Imperfecta 20
Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome

ARCS1

Arthrogryposis Renal Dysfunction Cholestasis Syndrome

Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

Arcs

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, And Cholestasis

Arthrogryposis-Renal Dysfunction-Cholestasis

Arthrogryposis - Renal Dysfunction - Cholestasis

Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1

Arthrogryposis Renal Dysfunction And Cholestasis 1

Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1

Kidney Failure

Renal Insufficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125218 PARP11 inhibitor ITK7 Inhibitor 99.77% Unkown
HY-148566 OUL232 Inhibitor 99.82% Unkown
HY-RS10053 PARP11 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PARP11 MGD MGI:2141505
Rattus norvegicus PARP11 RGD RGD:1561791
Bos taurus PARP11 VGNC VGNC:49073