Uts2r - urotensin 2 receptor Gene

Also Known as Senr; Gpr14; UR-2-R

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 57305

About Uts2r

Primary_assembly 10: 106,438,092-106,439,252 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 54 orthologues, 24 paralogues and is associated with 9 phenotypes.

Summary

Enables urotensin II receptor activity. Involved in several processes, including positive regulation of circadian sleep/wake cycle, REM sleep; positive regulation of circadian sleep/wake cycle, wakefulness; and regulation of blood pressure. Located in early endosome; plasma membrane; and recycling endosome. Used to study acute kidney failure; endomyocardial fibrosis; and hypertension. Biomarker of cardiomyopathy and myocardial infarction. Orthologous to human UTS2R (urotensin 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Uts2r Products (1)

mRNA Protein Name
NM_020537.1 NP_065412.1 urotensin-2 receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables urotensin II receptor activity IDA
IDA: Inferred from direct assay
16141412 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
16531985 RGD
involved in negative regulation of glomerular filtration IMP
IMP: Inferred from mutant phenotype
16531985 RGD
involved in negative regulation of urine volume IMP
IMP: Inferred from mutant phenotype
16531985 RGD
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
17089015 RGD
involved in positive regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
17900760 RGD
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
15549273 RGD
involved in positive regulation of circadian sleep/wake cycle, REM sleep IMP
IMP: Inferred from mutant phenotype
15944374 RGD
involved in positive regulation of circadian sleep/wake cycle, wakefulness IMP
IMP: Inferred from mutant phenotype
15944374 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
15549273 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
16919371 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
15554454 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17184580 RGD
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
16141412 RGD
located in recycling endosome IDA
IDA: Inferred from direct assay
16141412 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Uts2r Protein Structure

7tmA_UII-R

7tmA_UII-R: cd14999 (53 - 78)

7tmA_UII-R

7tmA_UII-R: cd14999 (53 - 327)

7tmA_UII-R

7tmA_UII-R: cd14999 (85 - 109)

7tmA_UII-R

7tmA_UII-R: cd14999 (122 - 152)

7tmA_UII-R

7tmA_UII-R: cd14999 (164 - 185)

7tmA_UII-R

7tmA_UII-R: cd14999 (207 - 236)

7tmA_UII-R

7tmA_UII-R: cd14999 (251 - 281)

7tmA_UII-R

7tmA_UII-R: cd14999 (295 - 320)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

urotensin-2 receptor

  • G-protein coupled receptor 14

  • G-protein coupled sensory epithelial neuropeptide-like receptor

  • UR-II-R

  • putative G protein-coupled receptor (SENR)

  • urotensin II receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15584 UTS2R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15585 Uts2r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15586 Uts2r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Uts2r NCBI NCBI:2837